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Plague Inc. Strategy Guide: Tips and Tricks

Sunday, June 3rd, 2012 by

plague inc guide

Welcome to our guide for Plague Inc. We hope it helps you in engineering your very own disease to unleash upon humanity.

(If you’re looking for a review of Plague Inc., click here.)

*** UPDATES ***

2014-03-16: Neurax Worm Abilities

2014-01-12: Added Strategy

2013-03-20: Necroa Virus Exclusive Transmission traits and Symptoms

2013-03-07: Necroa Virus Symptom Combos, Necroa Virus Genes

2013-03-03: Necroa Virus Symptom Combos

2012-12-31: Symptom Combos

2012-12-10: Scoring

2012-11-24: Disease Types, Abilities

2012-11-17: Disease Types, Symptoms, Abilities

2012-11-03: Added Modify Genetic Code

2012-10-21: Abilities

2012-09-23: Abilities, Disease Types, and Government Actions and Events

2012-09-15: Abilities

2012-09-08: Abilities, Disease Types, Symptom Combos, and Tips and Tricks

2012-09-01: Abilities and Tips and Tricks; added Government Actions

2012-08-18: Tips and Tricks

2012-08-11: Symptom Combos

2012-08-08: Added Follow the Developer

2012-08-05: Abilities, Symptom Combos, and Tips and Tricks; added Scoring

2012-07-19: Abilities and Disease Types

2012-07-15: Symptom Combos and Abilities

2012-07-11: Symptom Combos

2012-07-02: Added Ability Statistics, Cure Statistics, Symptom Combo Statistics, and Transmission Statistics

2012-07-01: Tips and Tricks; added Symptom Statistics

2012-06-24: Added Special Thanks

2012-06-23: Upgrade Chart: Abilities; added Symptom Combos

2012-06-09: Tips and Tricks, Upgrade Chart

2012-06-06: Tips and Tricks, Upgrade Chart; added Disease Types

2012-06-04: Tips and Tricks again, Upgrade Chart again

2012-06-04: Tips and Tricks, Upgrade Chart

2012-06-03: Upgrade Chart

2012-06-03: First version


FOLLOW THE DEVELOPER

ndemic creations plague inc. Ndemic Creations is a one-man team, so James Vaughan can use all the support and exposure he can get. If you love Plague Inc., be sure to follow him on Twitter and Facebook. You can also check out the Ndemic Creations website.


ALL YOUR BURNING QUESTIONS ANSWERED

plague inc interview

 

BASIC INFO

This is a summary of the “How to Play” info from the actual game, so that you can refer here while playing instead of quitting back to the title screen.

Start of Game

Select a Country: For easier transmission to other countries, pick a starting country with an aiport, seaport, and land neighbors. The poorer the country, the easier.

Middle of Game

News: Pay attention to the new blurbs at the top of the screen. Sometimes they’re silly, but often they’ll provide insight into which countries are recognizing the threat and how they’re reacting.

Deadliness: The more deadly your disease is, the more resistance you’ll get from governments. It’s up to you: play it cool and evolve lethality once your plague is widespread, or go for full-out carnage early and get a quicker victory, though with more resistance.

End of Game

Kill Everyone: Careful with your lethality, though, because there must be infected left at the end.

Check Statistics: See who is spending the most on a cure. Look for uninfected countries.

Disease Attributes

Infectivity: How quickly your disease transmits to other people.

Severity: How bad the symptoms are. Helps slow cure research and gives you more DNA points for upgrades.

Lethality: How easily it kills. Helps slow cure research and gives you more DNA points for upgrades. Don’t get this higher than your other attributes.

Evolution Categories

Transmission: Increases your Infectivity. Makes your disease more likely to mutate, which gives free upgrades.

Symptoms: Makes it harder for governments to research a cure.

Abilities: Customizes your disease against harsh climates, makes it harder to cure, etc.

How to Spread Your Disease

Inside a Country: Pretty much any evolution will help ramp up your disease within a country.

Between Countries: Spend DNA points on Transmission evolutions to help your plague cross borders.

Lockdown: Governments may close ports and borders, though animals can still cross. Island lockdowns are trouble.

Adapt to Different Countries

Country Overview: Touch a country’s name for info on climate, demographics, etc.

Country Climate: Evolve Transmission and Ability upgrades to counteract different climates.

Country Demographics: Evolve Transmission and Ability upgrades to counteract different demographics. Rich countries are harder to infect.

How to Stop the Cure

What It Is: The more scared a country gets, the more money they’ll spend on research.

Defense Against: Keep your disease from getting too scary too fast. Try to keep Severity and Lethality low until later in the game. Once your disease becomes really scary, evolve Abilities to help slow research for a cure.

Special Events

Research Teams: Blue planes traveling between countries indicate research teams. Pop the blue bubbles that come up to stop them.

Mutations: Get free evolutions over time. Buying Transmission upgrades involving animals will increase mutation frequency.

Government Actions: Watch the news to see when governments take big notice of your disease. Also check out country overviews from time to time.

TIPS AND TRICKS

Here are things that I and readers like you have figured out by playing that are good to know from the start.

  • Close all other apps. Plague Inc. eats memory like, uh, a memory-eating zombie, so give it your iOS device’s undivided attention. If you are running other apps, Plague Inc. may notify you that it needs to save and close because it doesn’t have enough memory.
  • Use a fun name. While a serious disease name like DeathKill can make you feel more badass, it’s funny as hell to keep seeing news about the worldwide plague known as FartyButt.
  • Game date. In the top-right corner is the date. Note that this is in Day Month Year format.
  • Speed controls. Tapping the game date drops a box that allows you pause the game, play in fast mode, or return to normal time flow. While paused, you can research upgrades or check on countries without being concerned about things getting out of hand. Ignoring the dropdown box for a few seconds makes it disappear.
  • Bubbles will pop when the game is paused. It just won’t look like it, because they won’t actually disappear until you unpause the game. Note that this is also true if you tap on a bubble while an alert is being displayed. UPDATE: A reader informed me that if you have auto-stop on, you can actually pop them while an alert is up.
  • Upgrading pauses the game. Well, mostly. When you go into the Disease menu from the bottom-left button on the main screen or the World menu from the bottom-right button, everything will be paused except for scrolling news messages at the top. This is great, because it means you don’t have to manually pause the game before upgrading.
  • Play in Fast-Forward. This may seem kind of scary, but since the game pauses whenever you go into the Disease or World menus, there’s really no reason not to accelerate your plague’s progress. The bubbles that pop up stay around just as long before fading in normal or fast-forward, so no worries there.
  • Evolution prices go up. The price of each unpurchased disease trait goes up by 1 whenever you buy something else. See Transmission Statistics and Symptom Statistics below for starting costs. Note that free upgrades via mutation do not increase the costs of unevolved traits.
  • You can devolve unwanted upgrades. If mutation gives you a trait you don’t want, such as something that increases Lethality before you’re ready for the masses to start giving up the ghost, you can devolve it from the appropriate evolution category. Doing so will give you a small amount of DNA points.
  • You may be warned about mutations beforehand. When you get notification that scientists have increased their understanding of a particular trait, any unevolved traits near that one are now more likely to mutate.
  • Focus on Transmission upgrades at first. Make your disease easy to spread before making it scary and lethal.
  • Focus on evolutions specific to your starting country at first. If your starting country has an arid climate, get Air 1. If it is humid, get Water 1. After your plague has spread to numerous other countries, then you can get a broader spectrum of upgrades.
  • Severity + Infectivity = More DNA Points. Severity and Infectivity affect the number of DNA points you get for infecting new countries.
  • Don’t wait too long to start killing. Too much Lethality early on is bad, but waiting until near the end will leave too many people to help with the cure, and you’ll end up losing.
  • Don’t ignore Transmission at the end. Yes, you need to kill a lot at the end, but you also need to make sure a solitary country isn’t going to hold out and prevent you from winning (annihilating all human life on the planet). Use the World menu to see which countries aren’t infected, look at their attributes, and evolve accordingly so that they can share in your armageddon.
  • Countries have a limit of severity until your plague is detected. This means you can let symptoms mutate and just leave them until that country’s tolerance level is closing in. You can gauge this based on the infected rate of the host country. You can usually run with coughing and sneezing to about 90%, then you will have to cancel one symptom. All this time you will get accelerated points for infecting new countries. Once cancelled, you go back to earning 1 point per country.
  • See user comments. Readers have dropped some solid strategy and info on getting achievements. Check it out!

STRATEGY

From UGA1998′s Comment

5 Star Plague Strategy

(This Strategy will get you a huge score if you master it. 100,000+)
-strategy uses bioweapon, which is unpredictable so it may take many attempts to get it right (sometimes the weapon can become very lethal too quickly so might want to bail on these games and start another round)
-This strategy takes a very long time. Not the way I originally started playing so you will want to know when to fast forward and when not to.
-please share your highest score using this strategy or if you are able to refine it and score more, please let everyone know the tweaks. My best is 190,000. If you tweak the disease and score more, let everyone know how you did it.

1. Get gene compression 1,2,3
2. (be prepared to get Deactivate Modified Genes 1,2,3 anytime the disease becomes lethal. Only three chances to set it back. It’s best to have the disease get lethal later in the game because it really cripples your game if your spending early game points on it)
3. Get Bird 1
4. Get Insomnia
5. Get Air 1
6. Get Paranoia either through purchase or mutation
6. Get Water 1
7. Countries will begin getting infected. You will 2 or 3 DNA points for each country with insomnia and paranoia. Your severity is pretty high so you have to watch the United States infectivity percentage. You will need to drop Paranoia around 40%. Drop Insomnia around 60%. Just buy coughing after this happens. You can have sneezing, but just devolve coughing so there is only 1 active symptom. you can wait on sneezing to mutate. Devolve all mutating symptoms from this point.
8. We have used the US strong drug capability against the world. Makes for a slow game, but who cares. You can infect about 1/2 all countries during this phase. After this you will only earn 1 point per country.
9. While you are infect countries Bird 2
10. Heat Resistance 1
11. Cold Resistance 1
12. Drug Resistance 1 (not until you are done getting points as described earlier)
13. Get Nucleic Acid Neutralization 1,2,3
14. That’s about it for spending right now. Just pool your points and hope the whole is infected before the disease becomes lethal.
15. You should have 70-120 DNA points now. The world is infected. What next? I like to wait for the disease to become lethal for the final time. It will kill off 6mil before starting cure, which will allow you quicker accumulation of DNA points for taking the population down.
16. Get Armaggedon (special ability of bioweapon that appears when you get gene compression 1-3, deactivate modified gene 1-3, and Nucleic acid neutralization 1-3.
17. From Sneezing get Immune Suppression
18. Total Organ Failure
19. Coma (you are probably about out of points now, you will have to wait for disease to start killing to get more)
20. Paralysis
21. Inflamation
22. Insanity
23. Paranoia and Insomnia
24. Spend extra if you have it on whatever. You won’t have many more points.
25. Goal is to keep cure under 10%. Do this and you should score more than 100,000 points and get a 5 star (biohazard) plague. Don’t be surprised if you game lasts 1000 days.

From Felix’s Comment

I have just completed the whole game on brutal. If you follow my strategy you can complete it easily. Start in Egypt, it is central has two ports and one airport.

Concentrate on transmission, first you never need to do more than 2 air and 2 water + bonus that unlocks, you don’t need pigeons or rats or any of that other crap.

Your aim is to get everyone in the world infected. Until this time other than coughing (which goes unnoticed and increases infection) do not develop any symptoms and devolve any that mutate.

Add abilities of two cold, heat if you want (I don’t bother) and 1 Drug resistance. Then wait. Keep checking Fast forward and just poop the infection and DNA bubbles. When everyone in the world is infected you should have around 100 DNA points. Evolve in one hit symptoms of:
Coughing>Pneumonia>Pulmonary Fibrosis>Total Organ Failure
Sit back watch the death toll rise and as you DNA points go for abilities of:
Genetic Hardening 1>Genetic Reshuffle 1

Then crank up the symptoms to slow the cure go:
Insomnia>Paranoia>Seizures>Insanity once you do that The cure grinds to a halt. If needs be evolve more genetic reshuffle. Done

This basic approach of concentrating on Transmission and devolving symptoms so it is not noticed until every one is infected works on every type. It only needs a little tweaking for some types:

Nano-virus: Evolve Code fragment interception and radical elements stabilized with your first 7 points, then go symptom coughing, then go for infection as previously described make sure you evolve code segment interception etc. But the same basic principal works.

Fungus: Save spore burst until you have two or one country left, be patient. When all countries are infected continue to be patient until all people are infected.

Bio-weapon reduce lethality as your first priority, then coughing, transmission, then again when everyone is infected, wallop, bang on the symptoms.

The principal works its about timing and not wasting your DNA points. I repeat you don;t need Blood, Livestock, Insect, Rodent, Bird transmission. Good luck.
PS the Special Cheats are not worth bothering with. If you’ve already beaten the game on Brutal why bother doing it with a cheat. I did evolve all symptoms on Unlimited plague and everyone was dead in 6 months. What’s the point of that?

DISEASE TYPES

Bacteria: Standard. No major strengths or weaknesses.
Bio-Weapon: Lethality increases as you play. Hard to transmit late-game because it kills so quickly.
Fungus: Bad spread. You’ll want to maintain strong focus on Transmission upgrades throughout the game.
Hidden Plague: Government will not do anything to stop your diesease from spreading.
Infinite Money: Start with 2000 DNA points.
Nano-Virus: Cure research begins as soon as the game starts.
Necroa Virus (ZOMBIES): Unclassified pathogen with extreme regeneration abilities, but the rest of its genetic code is a mystery. To win, you have to kill off the last human survivors OR turn them into zombies.
Neurax Worm: Burrows into brain and controls host. High Infectivity and Severity. Note: This disease type lets you win the game via the standard method of killing off humanity OR via enslaving humanity. Countries that worship the worm will stop all cure research.
No Cure: Cure research stops at 99%.
Parasite: No DNA points increase from infecting people.
Prion: Transmits more slowly. Symptoms decreased. Cure takes longer to research. Cure defense increased.
Virus: Mutates rapidly. You’ll get a lot of free upgrades, but you also may need to devolve some in order to maintain your strategy.

UPGRADE CHART

These are the evolutions on which you can spend DNA points. Tap “Disease” in the bottom-left corner, then click on the desired tab at the top. Each upgrade has a list of what traits are improved and indicates which other upgrades it unlocks, if any.

Transmission

Air 1: Infectivity in Arid Climates, Plane Transmission; [unlock] Air 2
Air 2: Infectivity in Arid Climates, Plane Transmission; [unlock] Extreme Bioaerosol if Water 2 upgraded
Bird 1: Infectivity, Land Transmission, Mutation; [unlock] Bird 2
Bird 2: Infectivity, Land Transmission, Mutation; [unlock] Extreme Zoonosis if Livestock 2 and Rodent 2 upgraded
Blood 1: Infectivity in Poor Regions, Mutation; [unlock] Blood 2
Blood 2: Infectivity in Poor Regions, Mutation; [unlock] Extreme Hematophagy if Insect 2 upgraded
Extreme Bioaerosol: Infectivity, Infectivity++ in Humid and Arid Climates, Plane and Ship Transmission++
Extreme Hematophagy: Infectivity, Infectivity++ in Poor Regions, Mutation
Extreme Zoonosis: Infectivity, Infectivity++ in Rural and Urban Regions, Mutation, Cross-Country Transmission++
Insect 1: Infectivity in Hot Climates, Mutation; [unlock] Insect 2
Insect 2: Infectivity in Hot Climates, Mutation; [unlock] Extreme Hematophagy if Blood 2 upgraded
Livestock 1: Infectivity in Rural Regions, Mutation; [unlock] Livestock 2
Livestock 2: Infectivity in Rural Regions, Mutation; [unlock] Extreme Zoonosis if Bird 2 and Rodent 2 upgraded
Rodent 1: Infectivity in Urban Regions, Mutation; [unlock] Rodent 2
Rodent 2: Infectivity in Urban Regions, Mutation; [unlock] Extreme Zoonosis if Bird 2 and Livestock 2 upgraded
Water 1: Infectivity in Humid Climates, Ship Transmission; [unlock] Water 2
Water 2: Infectivity in Humid Climates, Ship Transmission; [unlock] Extreme Bioaerosol if Air 2 upgraded

Necroa Virus Exclusive Transmission

Air 3: Virus replicates rapidly in aerosoled brain matter. Significantly increases risk of infection if interacting with zombie brains.
Bat 1: Host range broadens to include bats, which are hard to detect. Increases infectivity and mutation chance.
Bat 2: Partial genetic activation causes bats to mob and attack humans at night. Significantly increases infectivity, and attacks can be lethal.
Gastrointestinal Expansion: Virus can replicate in stomach and intestine, increasing infectiousness through feces and vomit.
Saliva 1: Virus replicates faster in salivary glands, increasing chance of infection through contact with saliva.
Saliva 2: Virus replicates directly in nasal cavity, significantly increasing chance of infection through contact with mucus.
Urogenital Expansion: Virus can replicate in kidneys and urinary tract, increasing infectiousness through urine and other bodily fluids.
Zoonotic Shift: Genetic shift in virus increases infectivity, mutation chance, and makes cross-species infection possible. Increases future research speed.

Transmission Statistics

Infectivity is used in the game to describe how easily the disease spreads from person to person within a country.

Transmission refers the ability for the disease to spread from country to country. Nonetheless, enhancing Transmission traits will also enhance the Infectivity. The stats for this are listed below.

Transmission traits have an inflation system, where the cost of a trait increases by 1 DNA pt for each prior trait you’ve obtained.

ComboBase DNA PointsInfectivity
Air 194
Air 2147
Bird 1123
Bird 2186
Blood 182
Blood 2134
Extreme Bioaerosol165
Extreme Hematophagy245
Extreme Zoonosis225
Insect 194
Insect 2208
Livestock 172
Livestock 2124
Rodent 1103
Rodent 2166
Water 194
Water 2158

Early in the game, it is generally cheaper to enhance Infectivity with Symptoms than with Transmission traits. Note that Insect 1 & 2, Air 1 & 2, and Water 1 & 2 are generally more cost-effective than other traits with respect to Infectivity.

Symptoms

Abscesses: Transmission; [unlock] Systematic Infection, Tumors
Anemia: Infectivity, Severity; [unlock] Hemophilia
Coma: Lethality, Cure Defense++; [unlock] Paralysis, Systematic Infection, Total Organ Failure
Coughing: Transmission in Urban Regions; [unlock] Pneumonia, Sneeze
Cysts: Transmission; [unlock] Abscesses, Hyper Sensitivity
Diarrhea: Transmission, Transmission++ in Poor Regions, Lethality, Lethality++ in Poor Regions; [unlock] Dysentery, Pulmonary Edema, Vomiting
Dysentery: Transmission, Lethality; [unlock] Diarrhea, Insanity
Fever: Infectivity, Lethality; [unlock] Immune Suppression, Skin Lesions, Sneezing, Sweating
Hemophilia: Transmission; [unlock] Internal Hemorrhaging, Tumors
Hemorrhagic Shock: Lethality; [unlock] Internal Hemorrhaging, Necrosis
Hyper Sensitivity: Severity, Severity++ in Rich Regions; [unlock] Inflammation, Paralysis
Immune Suppression: Mutation, Lethality; [unlock] Fever, Sneezing, Total Organ Failure
Inflammation: Lethality; [unlock] Hyper Sensitivity, Paralysis, Paranoia, Seizures
Insanity: Cure Defense++; [unlock] Dysentery, Seizures
Insomnia: Severity; [unlock] Paranoia
Internal Hemorrhaging: Lethality; [unlock] Hemophilia, Hemorrhagic Shock, Tumors
Nausea: Severity, Transmission; [unlock] Vomiting
Necrosis: Lethality, Transmission; [unlock] Hemorrhagic Shock, Skin Lesions
Paralysis: Cure Defense++, Lethality; [unlock] Coma, Hyper Sensitivity, Inflammation
Paranoia: Severity; [unlock] Inflammation, Seizures
Pneumonia: Severity in Cold Climates; [unlock] Pulmonary Edema, Pulmonary Fibrosis
Pulmonary Edema: Lethality, Transmission; [unlock] Diarrhea, Pneumonia, Pulmonary Fibrosis, Vomiting
Pulmonary Fibrosis: Lethality; [unlock] Pulmonary Edema, Pneumonia, Total Organ Failure
Rash: Infectivity; [unlock] Sweating
Seizures: Lethality; [unlock] Inflammation, Insanity, Paranoia
Skin Lesions: Transmission++; [unlock] Fever, Necrosis, Sweating
Sneezing: Infectivity++; [unlock] Fever, Immune Suppression
Sweating: Transmission, Transmission++ in Cold Climates; [unlock] Fever, Skin Lesions
Systematic Infection: Transmission++, Lethality; [unlock] Abscesses, Coma, Tumors
Total Organ Failure: Lethality++; [unlock] Coma, Immune Suppression, Pulmonary Fibrosis
Tumors: Lethality; [unlock] Abscesses, Hemophilia, Internal Hemorrhaging, Systematic Infection
Vomiting: Transmission; [unlock] Dysentery, Pulmonary Edema

Necroa Virus Exclusive Symptoms

Acidic Reflux: Extreme laryngopharyngeal reflux causes acidic saliva. Increases severity and gives zombies a combat advantage.
Acute Encephalitis : Multiple inflammatory lesions in the brain cause severe neurological damage, resulting in death.
Adrenal Surge: Mutation of the adrenal cortex causes adrenaline over-production, increasing alertness and aggression of zombies.
Anabolic Boost: Surges of testosterone significantly increase muscle mass and weight of some zombies. Severity significantly increased.
Anaerobic Resuscitation: Infected braincells switch to anaerobic respiration. Lactic acid buildup is lethal and destroys higher brain processes and personality.
Autolytic Delay: Virus slows release of digestive enzymes from cells’ lysosomes, slowing decomposition of corpse.
Autophagia: Compulsion to bite or partially devour own body, typically fingers or skin. Increases infection rates.
Autothysis: Explosive mix of hydrogen sulphide and methane collects inside zombie. Significantly increases severity and zombie combat advantage.
Bone Dysplasia: Increased bone density provides enhanced protection against trauma. Gives zombies a significant combat advantage.
Cannibalism: Extreme compulsion to bite and eat other humans, significantly increasing infectivity as well as lethality.
Cathemeral Shift: Stimulation of primary visual cortex improves vision in bright sunlight. Significantly increases severity.
Cranial Elephantitis: Adenoma triggers mutated growth hormones, which encourage bone growth in the skull. Gives zombies a combat advantage.
Cytopathic Reanimation: Formation of complex neural structures enables re-animation of damaged cells and restoration of low-level vitals. Turns dead into zombies.
Delirium: Reduction in cognitive function causes irrationality and paranoia. Can be fatal and significantly slows future research speed.
Dermal Calcification: Mutations in the endocrine system cause parts of skin to harden and calcify. Gives zombies a combat advantage.
Enhanced Motor Control: Nutrient flow to the parietal lobe increased, improving movement and coordination. Increases severity, particularly in urban environments.
Enhanced Sensory Integration: Nutrient flow to the occipital and temporal lobes increased. Enhanced sight and hearing increase severity.
Gastroenteritis: Inflammation of the GI tract causes frequent vomiting. Significantly increases infection rates.
Hyper Salivation: Inflammation of the submandibular gland increases saliva production and infection rates.
Hyperosmia: Thinning of the nasal epithelium significantly heightens zombie sense of smell. Increases severity.
Liquefactive Resistance: Virus denatures hydrolytic enzymes, slowing liquefactive necrosis and decomposition of the corpse.
Lumbrical Hypertrophy: Significantly strengthens zombie grip, making it nearly impossible for prey to break free. Severity significantly increased.
Masticatory Tension: Masticatory muscles become engorged, allowing zombie to bite through thick clothing. Severity increased.
Naja Mortis: Muscle growth around submandibular duct lets some zombies projectile-spit at prey. Increases severity and zombie combat advantage.
Peptide Surge: Growth hormone production triggers extreme metabolism of fat to build muscle. Enhanced strength increases severity.
Photophobia: Sensitivity and pain when eyes exposed to sunlight. Slows future research speed, but slightly reduces infection rates.
Polyphagia: Compulsive hunger forces continuous eating. Lack of hygiene increases risk of infection.
Psychosis: Psychotic episodes lead to occasional bursts of extreme violence, which can be lethal. Increases infectivity and slows future research speed.
Putrefactive Resistance: Virus prevents anaerobic microorganisms from digesting proteins, slowing decomposition of corpse.
Segmented Genome: Virus splits its genome into smaller molecules, increasing the likelihood of a viable mutation during transmission.
Temporal Lobe Manipulation: Zombies attracted to movement and will abandon victims once dead. Prey more likely to remain intact and become a zombie.
Vampiric Hunger: Zombie prefers to suck the blood from its prey rather than eat the flesh. Prey more likely to remain intact and become a zombie.

Symptom Statistics

Symptoms have an inflation system, where the cost of a trait increases by 1 DNA pt for each prior trait you’ve obtained.

SymptomBase DNA PointsInfectivitySeverityLethality
(nothing)00040100
Abscesses02040400
Anemia02010100
Coma21001502
Coughing*04030100
Cysts02020200
Diarrhea06060401
Dysentery19081508
Fever09040303
Hemophilia03040300
Hemorrhagic Shock23001515
Hyper Sensitivity02010200
Immune Suppression12020604
Inflammation05020202
Insanity18061500
Insomnia02000300
Internal Hemorrhaging12000907
Nausea02010100
Necrosis27102013
Paralysis10010501
Paranoia04000400
Pneumonia*03030200
Pulmonary Edema07050402
Pulmonary Fibrosis06030302
Rash*03020100
Seizures04010703
Sking Lesions*08110400
Sneezing*05050100
Sweating*03020100
Systematic Infection17060706
Total Organ Failure28002025
Tumors11020004
Vomiting03030100

* Particularly good at spreading infection with limited severity.

Total Organ Failure is the most deadly symptom by far.

Necrosis is great for killing while remaining infectious.

Symptom Combos

Oops: Sneezing + Diarrhea: Lowers productivity and increases awareness
Profuse Bleeding: Hemophilia + Skin Lesions: Infectivity++
Projectile Vomiting: Coughing + Vomiting: Infectivity
Public Defecation: Diarrhea + Insanity: Increase Research Speed (*** BEWARE ***)
Swine Flu: Nausea, Pneumonia, Vomiting, Diarrhea, Coughing, Sneezing, Insomnia, Paranoia, Livestock 1 & 2: Decrease Research Speed (10% increase in budget required for cure)
Walking Dead: Anemia + Insomnia: Decrease Research Speed

Necroa Virus Symptom Combos

Bath Time: Polyphagia + Autophagia + Cannibalism: Severity
Blood in the Air: Delirium + Hyperosmia: Severity
Boomer: Liquefied Organs + Authothysis: Severity
Cranial Dispersion: Cranial Elephantitis + Air 3: Transmission (?)
Tank: Anabolic Boost + Bone Dysplasia: Severity
Spitter: Naja Mortis + Enhanced Sensory Integration: Severity
Sprinter: Enhanced Movement Control(?) + Engorged Quadriceps: Severity
Walking Contradiction: Photophobia + Cathemeral Shift: Severity Decreased
Vampire Bat: Bat 2 + Vampiric Hunger: Severity; alerts zombies of nearby humans

Symptom Combo Statistics

ComboInfectivitySeverityLethality
Profuse Bleeding442
Projectile Vomiting410
Public Defecation200
Swine Flu???
Walking Dead000

Symptom combos are not reversible, even if you devolve the symptoms that led to them.

Walking Dead slows cure research, but doesn’t do anything else.

Abilities

Universal Abilities

Cold Resistance 1: Cure Defense in Cold Climates; [unlock] Cold Resistance 2
Cold Resistance 2: Cure Defense in Cold Climates; [unlock] Environmental Hardening if Heat Resistance 2 upgraded
Drug Resistance 1: Cure Defense in Rich Regions; [unlock] Drug Resistance 2, Genetic Hardening 1
Drug Resistance 2: Cure Defense in Rich Regions; [unlock] Genetic Reshuffle 1
Environmental Hardening: Cure Defense++ in Hot and Cold Climates
Genetic Hardening 1: Decrease Future Research Speed; [unlock] Genetic Hardening 2, Genetic Reshuffle 1
Genetic Hardening 2: Decrease Future Research Speed; [unlock] Genetic Reshuffle 2
Genetic Reshuffle 1: Decrease Completed Research; [unlock] Genetic Hardening 2, Genetic Reshuffle 2
Genetic Reshuffle 2: Decrease Completed Research; [unlock] Genetic Reshuffle 3
Genetic Reshuffle 3: Decrease Completed Research
Heat Resistance 1: Cure Defense in Hot Climates; [unlock] Heat Resistance 2
Heat Resistance 2: Cure Defense in Hot Climates; [unlock] Environmental Hardening if Cold Resistance 2 upgraded

Bacteria Abilities

Bacterial Resistance 1, 2, and 3: Cure Defense in All Climates

Bio-Weapon Abilities

Armageddon Gene: Lethality+++, Infectivity and Severity bars moved up to half-way point; [requires] Deactivate Genes 3, Gene Compression 3, and Nucleic Acid Neutralization 3
Deactivate Genes 1, 2, and 3: Slow Lethality growth
Gene Compression 1, 2, and 3: Reset Lethality and slow Lethality growth
Nucleic Acid Neutralization 1, 2, and 3: Reduce Lethality and slow Lethality growth

Fungus Abilities

Spore Burst 1, 2, 3, 4, 5, and 6: Infectivity++; Random country infected; [unlock] Spore Eruption
Spore Eruption: Transmission++; ~5 random countries infected
Spore Hardening: If you get all Spore Burst and Eruption abilities, this is unlocked; Random country infected every ~1 minute; Transmission+++, Infectivity+

Nano-Virus Abilities

Code Fragment Interception: Works like a Genetic Hardening; 10% increase to finding cure, +3 to Infectivity
Code Segment Interception: Works like Genetic Hardening 2; 30% increase to finding cure
Factory Replication Overload: Drastically increases Infectivity for a short time (time period varies as does the Infectivity increase); Infectivity +50 to +110; Once this time has expired, the disease’s Infectivity goes back to what it was, but with -5 Infectivity
Radical Elements Stabilized: Works like a Genetic Reshuffle on steroids; 100% increase to find cure
Encryption Breached: Same as Radical Elements Stabilized: 100% increase to find cure
Broadcast Interceptor Overload: Temporary 200% increase to finding cure (about 3 weeks); Once time is up the cure picks up where it left off, with time left for full cure slightly reduced; Tip:  If you use this right before you win the game you can decrease the cure progress before it has a chance to reset and increase your score by a lot of points! When there are about 500-5000 people still alive, activate this!
Drug Immunity Ability: Infectivity++ in wealthy countries (requires Drug Resistance 2 for sure, and may require Code Fragments and/or Radical Elements)

Neurax Worm Abilities/Transmissions

Air 1: Worm can dehydrate to become lighter, allowing them to float on wind, increasing Infectivity, especially in arid conditions and planes
Air 2: Carapace becomes lighter, increasing Infectivity, especially in arid conditions and planes
Air 3: Waxy membranes allow survival in air conditioning vents and other arid locations. Increased Infectivity, especially in rich and hot countries
Bird 1: Worms become a food source for birds, but many survive in the digestive tract, allowing increased Transmission
Bird 2: Worms develop the ability to breed in the bird’s digestive tract, allowing greater distribution and Transmission
Corpse Feeder 1: Worms drawn to corpses, increasing Infectivity when corpses present
Corpse Feeder 2: Worms undergo feeding frenzy in corpses, significantly increasing Infectivity when corpses present
Eggs 1: The Neurax worm produces eggs that are ejected from the host brain in the thousands, increasing Infectivity
Eggs 2: Eggs hatch when they experience an increase in warmth, likely due to nearby human activity, greatly increasing Infectivity
Genetic Swap: Worms able to exchange genetic material inside host body, increasing chance of Mutation
Insect 1: Worm eggs attach themselves to insects, causing increased Infectivity, especially in hot climates
Insect 2: Attaching to a greater range of insects allows a large increase in Infectivity, especially in hot climates
Locomotion, Concertina: Ability to grip with portions of the body while pulling/pushing other sections allows faster movement outside host, increasing Infectivity
Locomotion, Undulatory: Ability to propagate flexural waves along the length of worm allows an increase in speed and range outside host, increasing Infectivity
Mutative Regeneration 1: Fragmented RNA strands causes frequent replication errors when regenerating and an increased chance of Mutation
Mutative Regeneration 2: Degradation of the nuclear membrane makes the worm highly prone to Mutation
Rodent 1: Worm eggs attach themselves to the fur of rats, which increases their Infectivity, especially in urban environments
Rodent 2: Worm eggs secrete a neurochemical that drives rats to attack humans, increasing Infectivity, especially in urban environments
Trojan Planes 1, 2, and 3: Increases likelihood of Trojan Plane bubble (ability to make a plane go wherever you want); note that when playing the Neurax Worm, you will sometimes get these bubbles even without purchasing the abilities
Trojan Roamers 1, 2, and 3: Increases Infectivity/Severity; increases ability of Transmission by person to another country through land borders
Trojan Destroyers 1 and 2: Increases Infectivity/Severity; better likelihood of infection and death in the country in which the Trojan Plane lands
Water 1: Worm skin becomes highly vascularized allowing absorption of oxygen, survival and Transmission in water.
Water 2: Worms develop a more flexible cell membrane, which allows them to survive at a range of depths
Water 3: Worm eggs gain ability to thrive in unsanitized water, greatly increasing Infectivity, especially in poor countries

Parasite Abilities

Symbiosis 1, 2, and 3: Decreases Severity by 4, 8, and 10 pts; Symbiosis 3 also increases Infectivity by 2 pts

Prion Abilities

Neural Atrophy 1, 2, and 3: Cure Defense+ for 1 and 2, ++ for 3

Virus Abilities

Viral Instability 1, 2, and 3: Mutation++

Ability Statistics

Abilities have an inflation system, where the cost of a trait increases by 1 DNA pt for each prior trait you’ve obtained.

ComboBase DNA Points
Cold Resistance 17
Cold Resistance 212
Drug Resistance 111
Drug Resistance 225
Environmental Hardening30
Genetic Hardening 17
Genetic Hardening 222
Genetic Reshuffle 117
Genetic Reshuffle 221
Genetic Reshuffle 325
Heat Resistance 111
Heat Resistance 222

Genetic Hardening 1 slows research by 10%, which means the number of days to until the cure is increased by 11% (assuming no other changes).

Genetic Hardening 2 slows research by 40%, which means the number of days to until the cure is increased by 67% (assuming no other changes).

As mentioned below in Cure Statistics, each Genetic Reshuffle increases the amount of research required for a cure by 25%. This 25% corresponds to 4.75m in brutal mode, and 6.25m in normal mode.

Cure Statistics

You start a game with the base level of research that is required for the cure (19m for brutal, 25m for normal). The amount of research required to achieve the cure is then modified based on the symptoms and abilities you gain:

Symptoms (% of base)

Total Organ Failure: +0%
Insomnia: +3%
Paranoia: +6%
Paralysis: +10%
Insanity: +20%
Coma: +24%
Any other symptom: +1%

Abilities (% of base)

Genetic Reshuffle 1: +25%
Genetic Reshuffle 2: +25%
Genetic Reshuffle 3: +25%

MODIFY GENETIC CODE

DNA Genes

ATP Boost: 8pt bonus DNA boost at the beginning
Cytochrome Surge: Popping orange DNA bubbles now worth 4 pts
Metabolic Jump: Popping red biohazard bubbles now worth 4 pts
Catalytic Switch: Popping blue cure bubbles now worth 2 pts
Metabolic Hijack: Orange and red bubbles are auto-popped (really useful if you have end up spreading your plague so fast that you can’t pop the bubbles fast enough)

Travel Genes

Teracyte: + chance of plague spread by land
Aerocyte: + chance of plague spread by air
Aquacyte: + chance of plague spread by sea
Suppression: Plague more likely to cross a closed land-border
Native Biome: + Infectivity in your starting county

Evolution Genes

Ionised Helix: Bonus DNA when devolving = +4
Translesion: Costs to devolve don’t increase
Sympto-Stasis: Symptom costs don’t increase but disease is easier to cure
Patho-Stasis: Ability costs don’t increase but disease is easier to cure
Trans-Stasis: Transmission costs don’t increase but disease is easier to cure (good if you are the type to buy your abilities and transmission first to let your plague spread and then strike, as you’ll have a whole lot of DNA points left to spend!)

Mutation Genes

Darwinist: + chance of mutation
Creationist: – chance of mutation
Genetic Mimic: Plague harder to cure
Base Oxidisation: Plague can mutate transmissions but disease is easier to cure
Base Hydrolysis: Plague can mutate abilities but disease is easier to cure (mutation genes need a kick-start; they are slow to react unless you buy transmission/symptoms/abilities that also encourage mutation, then they can take off)

Environmentalist Genes

Xerophile: Gives plague bonus in arid climates
Hydrophile: Gives plague bonus in humid climates
Rurophile: Gives plague bonus in rural environments
Urbophile: Gives plague bonus in urban environments
Extremophile: Gives plague a minor bonus in all environments

Necroa Virus Genes

Autolytic Reduction: Slightly reduces zombie decay speed
Cytopathic Boost: Increases chance of infected corpses reanimating as zombies
Dopamine Inhibitor: Zombie victims are more likely to become zombies
Spliced Activation: Active abilities cost less DNA to use
ThermoNecro: Reduces zombie decay speed in hot countries

GOVERNMENT ACTIONS AND EVENTS

Ban Livestock Movement: slows Livestock Transmission
Blood Test: slows blood Transmission
Burn Corpses: stops Necrosis
Corp Disposal: slows Necrosis
Cull Livestock: stops Livestock Transmission
Cure Research: speeds up cure
Curfews: slow Infectivity
Distribute Insect Repellent: slows Insect Transmission
Exterminate Birds: stops Bird Transmission
Exterminate Pigeons: slows Bird Transmission
Exterminate Rats: slows Rodent Transmission
Exterminate Rodents: stops Rodent Transmission
Face Masks: stops Coughing, Sneezing, etc; slows air Infectivity
Fallen Government: stops cure for country
Health Care: slows plague in general (??)
Hot Water Bottle: stops Infection via water drinking
iCure Device: speeds up research; counter with Sweating, which breaks device
Insecticide Spraying Campaign: stops Insect Transmission
Martial Law: stops water Transmission
Shut Borders: stops cure from getting in or out via people

SCORING

We don’t have definitive data on this yet, but here is what commenter UGA1998 has come up with:

From the best I can tell it is a combination of:

  • Quickness (days)
  • Cure Percentage Rate
  • Strength of Plague (infectivity, severity, and lethality)

I tracked this for a while and came up with these scores. The first number in the series is infectivity, then severity, lethality, days, cure percentage and finally score:

(91,113,91,1075,8%)       122,740    5 star “biohazard symbol” plague
(118,93,87,785,51%)       18,170     3 star plague
(95,83,90,947,79%)         10,140
(92,126,57,449,53%)       29,750     3 star plague
(60,91,89,772,10%)         80,690     4 star plague
(84,92,84,722,19%)         43,440     4 star plague
(91,102,91,626,10%)       103,410   5 star plague
(110,100,94,596,22%)     44,350     4 star plague
(86,95,89,932,5%)          190,600   5 star plague
(94,103,89,1405,8%)      99,350     4 star plague

I haven’t analyzed these numbers to see how a score is derived and there may be other factors I haven’t considered, but I think this is pretty close. I’ve also noticed if you disable symptoms at the end of the game to get enough DNA points to buy something else, you seem to get penalized in the final score.

*******

Here’s some more info from TO_Asylum:

Getting a high score is a separate objective from winning the game – you can win, but getting a high score requires additional work. Some basic regression shows that score depends almost entirely on two factors: cure % at the end and difficulty level. These two factors correlate most strongly, with high statistical significance. In the data I collected (see below) other factors such as days and virus type do not correlate, although I’ve only looked 2 plague types in detail (bio-weapon and virus). The data from UGA1998 support the dominant relationship with cure; however, that data doesn’t include difficulty level. UGA’s data also shows some correlation with days (wasn’t the case in my data), and a weak correlation with infectivity/severity/lethality (not statistically significant).

Here is the supporting data. Difficulty is Casual=1, Normal=2, Brutal=3. Plague Types are Virus=2, Bio-Weapon=7.

(Difficulty, Plg type, Days, Cure%, Score, Star)
(2, 2, 940, 57%, 6050, 3)
(3, 2, 1138, 80%, 6660, 3)
(1, 7, 641, 20%, 7850, 3)
(3, 2, 1198, 49%, 13010, 3)
(1, 7, 428, 10%, 14590, 3)
(3, 7, 883, 57%, 16130, 3)
(2, 7, 797, 24%, 18080, 3)
(2, 7, 573, 21%, 20610, 3)
(3, 7, 587, 37%, 28190, 3)
(3, 7, 641, 25%, 32810, 4)
(3, 7, 632, 10%, 79670, 4)
(3, 7, 526, 8%, 81280, 4)
(3, 7, 637, 8%, 90510, 4)
(3, 7, 676, 8%, 92650, 4)
(3, 7, 573, 7%, 125530, 5)

As you can see in both data sets, you have to get under 10% to get close to or above 100k. As far as stars go, they seem to line up pretty clearly with score: you’re stuck at 3* until you break 30k, and no 5* until after 100k.

In terms of strategy, I followed a mix of felix and UGA’s. The general notion was:

  • Transmit under the radar (devolving all but cough) using air1,2 and water 1,2, sometimes throwing in something else (e.g., bioaerosol, or cold 1,2 if starting in a hot climate, or needles when Africa is slow)
  • If playing on bio-weapon, use all the abilities on the right (gene compression, etc) to unlock annihilate
  • Kill as fast as possible when the whole world is infected (e.g., annihilate on bio-weapon, or rushing to total organ failure on others)

*******

And some more from Mike:

To crack a score in hundreds of thousands and even millions, First u need to play on brutal, Second u need a cure rate of 4% or less. days doesn’t matter. However complexity of disease is huge. First it lets you get a low cure rate, second it increases your score by rewarding you for evolving your disease.

To accomplish this, u need to infect the entire world, and then evolve every symptom and all drugs, gene hards and reshuffles. you’ll score even bigger by evolving every transmission and ability, but you likely won’t have enough DNA for that. The more complex ( more evolved traits) your disease, the higher your score and the lower your cure rate.

The last factor, will take your score from hundreds of thousands to millions is leftover DNA. You won’t have any in parasite. But you will in worm and nano virus. Worm because you can keep sending Trojan planes indefinitely. And nano virus because of DNA loophole.

SPECIAL THANKS

My gratitude goes out to these individuals that commented below with tips and other info:

Andrew Staley: Prion abilities
Anonymous: Coughing goes unnoticed
anwipe: Popping bubbles during alerts
Big Irms: Alternate method for victory with Neurax Worm, strategy, Modify Genetic Code, Necroa Virus Symptom Combos
BWrabbitgirl: Swineflu combo clarification
Cadogan: Swineflu combo
Carter: Symptom combos, Extreme Hematophagy
Denise: Strategy
Derkurnen: Nano-Virus: Drug Immunity Ability
DonJacobo: Strategy, “second wave” idea
Donovan Haupricht: Necroa Virus Symptom Combos, Necro Virus Genes, Necro Virus Description
EzioAuditore59: Necroa Virus Exclusive Transmission traits and Symptoms, Neurax Worm abilities
FahrenheitBlack: Oops symptom combo
Felix: Strategy (a lot)
Gwarthon: Bio Aerosol
grasscid: Corrections to Disease Types, Symptoms, and Abilities
Hedrax: Necroa Virus Symptom Combos
HighlandRose: Sneezing goes unnoticed for a good while
IanXO4: The data for all the Statistics sections!!
Kusanagi: Symbiosis and Parasite
LapisChocolate: Disease-specific abilities (partial info)
loox: Bio-Weapon, strategy
Marcus: Strategy
Mike: Strategy, scoring
Mike Y.: Clarification on Genetic Hardening and Reshuffle
oilman: Swineflu combo (partial info)
oli the plague: Bio-Weapon abilities, mutation info, Government Actions, Neurax Worm abilities, disease types
Plague: Extreme Zoonosis
PlagueMakuta: Symptom combos, nukes, space mission, added to DonJacobo’s “second wave” idea, special plagues
RejectionHurts: Disease types
RushJet1: Spore Hardening
Rob: Symptom combos
Sophia: iCure Device event
stu-in-flag: Achievements
TO_Asylum: Scoring
TofuCurry: Clarification on Trojan Planes
tomtortoise: Symptom combos
Trinity: Symptom combos
UGA1998: Swineflu combo, DNA point, countries’ limits of severity until plague detected, scoring (partial info), strategy, Nano-Virus abilities, achievements
What the french toast: Achievements

About the Author

Markham Asylum is a founding member of Delta Attack. His tier-1 favorite genres are role-playing, puzzle, and strategy. His tier-2 are adventure, shooter, and platformer. He strives to provide spoiler-free postings whenever possible.

Markham Asylum has written 422 posts on Delta Attack
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  • Fade to Slack

    Wow. This looks great, sir. Pretty comprehensive.

    If you want to make a table like those found in the recipe guide, I can show you how to use the CSV stuff.

    • Markham Asylum

      Thanks, bro.

      • http://none ButterScotchCookie

        I’m having trouble with this game on android for some reason. I played, and defeated Normal mode on Bacteria, but when I went to play another game, it didn’t unlock anything. Please reply. Oh, and how do I get a refund for the “cheat” ? I purchased it, but I thought it would unlock everything (whole game) so it’s my arrogance really. Please let me know. Thanks!

        -ARasool [reddit]

        • Markham Asylum

          Hey ButterScotch, winning with a disease type on any difficulty higher than Casual unlocks the next disease. Are you sure you beat it? If so, did you actually wait until it finished saving your progress? I can only speak for the iOS version, but it seems like it would work the same way on Android.

          As for refunds, you’ll have go through whatever channels Google has for requesting such things.

        • Anonymous

          Mine does the same! And I’m on iPhone! I 100% beat the world and it came up with defeat?!? Please sort this creators! :(

          • Anonymous

            I had the same problem, and discovered that i need EVERYONE on earth to be infected and killed. If there’s still people alive that are not infected, you didn’t win..

            • Gabriel

              Same problem, make sure it keep an eye on New Zealand, Greenland and Iceland. people usually survive there.

  • RejectionHurts

    Keep in mind that there are multiple disease types, bacteria is the one initially unlocked. A virus will mutate randomly at a much higher rate and it actually costs points to devolve any symptoms mutated. After virus there is fungal spore which requires more attention to transmission as it can’t really spread very easily. That’s where I’m at now.

    • Markham Asylum

      Thanks for the pointers, Rejection. Sounds like you’re farther than me. I’ll add info on the other disease types soon.

  • BusyMom

    Do you really think breaking the blue bubbles slows down the cure? I don’t know if it actually makes a difference. I’ve gotten to the point where everybody is infected, I’ve killed off about half the world, and the cure progress sky-rockets. Is there anything I can do at that point to slow it down, or do I just need to be more prepared?

    • Markham Asylum

      Hey BusyMom, I do think the blue bubbles help, but only slightly.

      When you get to the point you describe, how full are your meters for Infectivity, Severity, and Lethality?

    • Mike

      Slowly infect the entire world without any symptoms, saving up as many DNA points as you can. Once you are @ 100%, strike hard and fast. Go directly to Total Organ Failure along a symptom root which has not given you warning that doctors can cure it more quickly. The population will drop so quickly that the cure will never be found in time.

      • Markham Asylum

        Simple and effective. Thanks, Mike!

      • Anonymous

        I do roughly the same thing but have found coughing to be a virtually invisible symptom being it won’t increase severity or lethality won’t be noticed and slightly boosts infectivity

        • HighlandRose

          Sneezing does a great job of that, too, and it’s not noticed overly quickly.

          • Markham Asylum

            Good tip. Thanks, Rose.

            • blackwolf

              actually I’ve found if you choose two symptoms and have little severity, a doctor in some random country discovers the disease, so unless you have parasite with the symbiosis ability, don’t have more than one symptom active at a time, focus on transmission instead.

              • Markham Asylum

                Nice one, blackwolf.

                • iHACKER KAY

                  widdle waddle i want to eradicate the human race good sir!

                  • Markham Asylum

                    Feel free, Kay. Game’s all ’bout it.

    • rich LePeter

      Yes, popping the blue bubbles adds about five days to the cure time in the games I’ve checked.

  • Gwarthon

    Nice work. Just so you know you are missing some transmissions and abilities though. For example if you get Air II and Water II it will unlock a combined trait that is really strong. Same goes with some of the abilities such as heat and cold resistance.

    • Markham Asylum

      Thanks, Gwarthon. Yeah, I was pretty sure I hadn’t seen all the upgrades yet.

    • Anonymous

      I believe it’s called bio aerosol and it is listed

      • Markham Asylum

        Yup, I just added it yesterday.

        • Anonymous

          Also get all the animals to upgrade two and a new upgrade for that appears

          • Markham Asylum

            Thanks, but that’s already on here.

  • Plague

    There is also “extreme zoonosis”. I got it after upgrading Bird, Rodent an Lifestock each to level II. Though I’m not sure if you need all three of them. Lifestock was the last upgrade before the zoonosis showed up. So maybe Lifestock and one the other two would be enough.

    • Markham Asylum

      Good tip! I’ll be sure to unlock it and add it on here. Thanks.

    • B0N3s

      Bird and Lifestock get extreme zoonosis,
      with extreme zoonosis i was able to infect both new guinie and the carribean after they closed their boarders and dropping the the rest of the worlds population to less than 5% before romoving my leathality and waiting approx. 10-20 min real time for the two islands to be infected by non-humans

    • Anonymous

      You do need all three animal transmissions to get extreme zooinosis

  • Marcus

    I had the same problem with the research skyrocketing when I lowered the boom. I would concentrate on transmission, resistance and finally symptoms. My first symptoms focused on death, but I now throw in ones that add lethargy and insanity. These symptoms seem to stop the research cold. Other non lethal symptoms might help too Watched too many movies where one of the scientists gets infected and can’t work on the cure.

    Marcus

    • Markham Asylum

      I agree, Marcus. The abilities listed with Cure Defense are definitely necessary mid- to late-game.

  • Felix

    I have just completed the whole game on brutal. If you follow my strategy you can complete it easily. Start in Egypt, it is central has two ports and one airport.

    Concentrate on transmission, first you never need to do more than 2 air and 2 water + bonus that unlocks, you don’t need pigeons or rats or any of that other crap.

    Your aim is to get everyone in the world infected. Until this time other than coughing (which goes unnoticed and increases infection) do not develop any symptoms and devolve any that mutate.

    Add abilities of two cold, heat if you want (I don’t bother) and 1 Drug resistance. Then wait. Keep checking Fast forward and just poop the infection and DNA bubbles. When everyone in the world is infected you should have around 100 DNA points. Evolve in one hit symptoms of:
    Coughing>Pneumonia>Pulmonary Fibrosis>Total Organ Failure
    Sit back watch the death toll rise and as you DNA points go for abilities of:
    Genetic Hardening 1>Genetic Reshuffle 1

    Then crank up the symptoms to slow the cure go:
    Insomnia>Paranoia>Seizures>Insanity once you do that The cure grinds to a halt. If needs be evolve more genetic reshuffle. Done

    This basic approach of concentrating on Transmission and devolving symptoms so it is not noticed until every one is infected works on every type. It only needs a little tweaking for some types:

    Nano-virus: Evolve Code fragment interception and radical elements stabilized with your first 7 points, then go symptom coughing, then go for infection as previously described make sure you evolve code segment interception etc. But the same basic principal works.

    Fungus: Save spore burst until you have two or one country left, be patient. When all countries are infected continue to be patient until all people are infected.

    Bio-weapon reduce lethality as your first priority, then coughing, transmission, then again when everyone is infected, wallop, bang on the symptoms.

    The principal works its about timing and not wasting your DNA points. I repeat you don;t need Blood, Livestock, Insect, Rodent, Bird transmission. Good luck.
    PS the Special Cheats are not worth bothering with. If you’ve already beaten the game on Brutal why bother doing it with a cheat. I did evolve all symptoms on Unlimited plague and everyone was dead in 6 months. What’s the point of that?

    Cheers

    • Gabe

      Thank you Felix! I’ve managed to beat it for the first time with your help. I shall try alternatives to dig in on more fun possibilities, but your strategy is exceptional! Thanks again for sharing!

      • Gabe

        I named my disease BaconFart one of the many fun things about this game!

        • Markham Asylum

          Huh huh, huh huh, you said “fart”.

          Heh heh, m heh! Yeah yeah!

        • Brian

          naming your disease “love” makes for a good laugh :)

          NEWS: love is spreading.

          NEWS: thousands of people infected with love.

          P.S. you can also replace “love” for “laughter” :)

          • Markham Asylum

            Nice one! lol, “Love Awareness Day”.

          • B0N3s

            Love has killed more than the Smallpox

        • Cheez

          Been using names like “idiocy” & “stupidity”… Blends nicely with the media announcements

          • Anonymous

            Your Mum spreads to Africa! Great fun.

            • Markham Asylum

              No, -your- mum spreads to Africa.

              lol, great disease name.

              • http://www.deltaattack.com/2012/06/03/plague-inc-guide/ Alex

                Funniest names me and my friends have done and won with!

                Your Mom has successfully eraticated all life on earth.
                God has successfully eraticated all life on earth.
                Chuck Norris has successfully eraticated all life on earth.
                All life on earth has successfully eraticated all life on earth.

                Oh here’s one we lost with but still funny.

                Everyone has been eraticated.

                • Markham Asylum

                  Good ones, Alex. I especially like “Your Mom” (who doesn’t?) and “Chuck Norris”.

                  • FappingDomo

                    To make the game seem more hyper realistic i name it Swag

        • Regret

          My disease is usually called virginity. There’s a cruel irony in making everyone else forever alone too…

          • Markham Asylum

            That’s perhaps the best disease name I’ve heard yet.

            • Tomtomo

              I call my disease Derp!

        • UltimateNinjaDude

          I got the BEST NAME EVER FOR PLAGUE:Communism
          “Communism starts in Russia!”
          “Communism spreads to the USA!”
          (if you look at the world graph often) “Communism has not been noticed!”
          “Communism threatens the world!”
          “Communism has successfully eradicated all life on Earth!”
          “Finland has fallen into anarchy due to fear over Communism!”
          “Communism is global!”
          “communism to be eradicated!” <—–(YESS!)
          "The last healthy person on the planet has been infected with Communism!"
          ITS PERFECT!!

          • David

            I’ve played this game several times. Beaten each disease type on Normal and Brutal mode. To this day, the most successful, the quickest killer, my HIGHEST score…was “Religion.” :P

    • Markham Asylum

      Epic comment, and great strategy. Many thanks, Felix.

    • Wren

      This strategy worked really well at first for viruses, but turned out to be too lethal and killed all the hosts, making some countries become healthy again. Help please.

      • Markham Asylum

        It should work. Did you devolve all spontaneous symptoms until everyone was infected?

    • Jack

      Well, that definitely worked!

    • loox

      The only thing I would add is that you don’t need any symptoms to kill on bioweapon. There is a ANNIHILATION Ability specific to Bio-Weapon that will kill all infected people in about a minute.

      1. On Brutal (and thus Normal) it is much quicker to evolve all three special abilities… the first two (the ones on the top) should be upgraded as early as possible … this brings lethality below zero (a negative value!)

      2. keep upping transmission and devolving all symptoms except couging AS SOON AS the the pop-up message appears.

      3. Then evolve the third special ability as soon as you notice people dying (it resets the lethality to zero)…. as needed use the Reset Ability II and then Reset III… this unlocks ANNIHILATION!!!

      4. Wait for everyone in the world to become infected…and I do mean EVERYONE… keep devolving symptoms, keep transmission very very high (birds are good here), and fight cure if necessary… just save enough points for annihilation… which is only 21 DNA points or so… sell transmission traits if you have to.

      5. When everyone is infected… evolve ANNIHILATION.

      6. World dead in less than a minute.

      (also, these special traits are VERY cheap… the most expensive one, Annihilation, is about 20 points… whereas total organ failure is 30 something points and you have to spend 50 points to reach it!)

      • Markham Asylum

        Great tips for Bio-Weapon! Many thanks, loox.

    • Tom

      Great advice I went from viral weenie to dominating with these tactics.

    • rex

      I need some help with fungus I can’t seem to slow the cure enough

      • Markham Asylum

        Rex, are you focusing on Transmission traits?

  • Carter

    There are several disease combinations that I have found. One is walking dead sympto combinations. Uses insomnia and anemia and it reduces the speed at which the cure is developed. Another one is projectile vomite which uses coughing and vomiting. It increases infection rates. There is one more I have found but I clicked out to fast to read it.

    • Markham Asylum

      Nice, thanks Carter.

  • Carter

    Level II insect and level II blood unlocks extreme hematophagy which gives increased mutation and infection in poor areas.

    • Markham Asylum

      Thanks again.

  • Denise

    My strategy here is always infect everyone first and not having any symptoms. This will make everyone infected without them noticing. Then when everyone’s infected, that’s when I start going for the symptoms at once. :bd

    • Markham Asylum

      That does seem to be a common strategy amongst people that have commented on this guide.

      • PlagueMakuta

        Yes, it does.

  • logan

    i used this guide and its certainly helping now all i need is practice, but i LOL’d when i got a notice about bellyflop awareness day

    • Markham Asylum

      I love the Awareness Day popup. I too was LOLing at “Fartybutt Awareness Day”.

      • PlagueMakuta

        LOL;

        Wake up late awareness day :d

  • Rob

    Anemia+ensomnia= walking dead. (Decreased research speed)
    Coughing+vomiting= projectile vomit (increased infectivity)

    • PlagueMakuta

      haemophilla + skin leisions = profuse bleeding (extremely increased infectivity)

    • trinity

      diarrhea + insanity= public defecation (increases research speed)

      • Markham Asylum

        These have all been added. Thanks, everyone.

  • ajb

    dose any one no how to get the usa to nuke russai or china. it is one of the acivements but i cant find how to do it

    • Markham Asylum

      I’m not sure how to do that. Maybe if you pick Russia or China as your starting country, but that’s just a guess.

    • Anonymous

      I really want to get them as well, I tried paranoia in USA but it didn’t work at all. Also, I can’t get the one about infecting astronauts. Any help, anyone?

      • jesus

        not sure if this will help but i know that there is a news bulletin that tells you when they’re about to launch into space. maybe hold off symptoms until you see that bulletin and then mess around with symptoms to try and infect them.

        • Markham Asylum

          Hmm, could be. Anyone get either of these achievements?

          • PlagueMakuta

            Start in russia or china, make it go to usa as soon as possible, and then make it really scary.

          • PlagueMakuta

            Also, for space: start in usa, when they launch into space make it as infectious as possible and evolve cold resistance. Nano-virus is best for this.

            • Anonymous

              To have a country nuke another, don’t you need to get neural worm expansion pack?

              • Court 11 ADA

                Using the Nero worm would be the logical option based on what he said. You could buy all those infected planes then send them directly over to the USA. That way, you avoid infecting a bunch of other countries, and when you make it lethal, 90 other countries won’t be researching for the cure

                • Court 11 ADA

                  Scratch that. It’s really hard to do, not impossible, for the Nero worm. Because your whole world is dead for good after it’s infected you’ll have to wait for them to die. I was successful on the immune cheat, you can build it however you want for as long as you want in there never gonna find a cure. In immune, Get to the point where some USA citizens are dying but the majority remain alive yet infected and the president will become ill, evolve the insanity symptom, Sarah Palin will take office, then increase fatalities a little bit, severity a lot, and wait for her to nuke Russia

  • CC

    I love this game but I always go mad trying to kill everyone straight away. I’m not patient enough to wait for everyone to get infected.

    • Markham Asylum

      Patience, young Padawan. Remember that impatience is the path to the Dark Side.

      • Extremo41

        Given the fact you are killing the entire population, I would say you are on the dark side anyway.

        • Markham Asylum

          Nice. I’m glad someone caught that.

          • Herbice

            Unless your Plague is “The Good Guys…” :P

  • ROFLMAOmatt

    Ok so I’ve managed to infect the entire world without any symptoms or abilities. Which symptoms should I use to wipe out everyone quickly and effectively? Oh and I’m playing as Bacteria.

    • Markham Asylum

      The advice above from Felix is pretty sound:

      Coughing > Pneumonia > Pulmonary Fibrosis > Total Organ Failure

      I’m pretty sure Total Organ Failure is the most lethal symptom.

      • ROFLMAOmatt

        Thanks man! This really helped me out :D

        • Markham Asylum

          Glad to help you rain death upon the world, Matt. >:-}

      • loox

        If you have the points, you can get COMA right below Total Organ Failure– IT REALLY SLOWS THE CURE… then PARALYSIS directly below COMA… this slows the cure as well… Much cheaper than working your way over to Insanity.

        • Markham Asylum

          That’s a good idea, loox. If Total Organ Failure doesn’t clinch it, those two would definitely help.

  • DonJacobo

    I just played bacteria/normal with a more aggressive “Second Wave” tactics. I started out with focus on transmission and mutation. Let the decease spread and become as nasty as possible, but save up DNA. Use no abilties to make the cure harder to find. Let the poor humans research. By the time there was a 100% cure I had 100% infected peple in the world, a semi-nasty decease and 100+ DNA to spend. I let the cure work until 50% was cured.

    Time for the Second Wave!

    I went all-in on drug resistance, genetic hardening and DNA reshuffle. The cure dropped down to 70% and people got re-infected again giving a huge DNA boost. I almost managed to evolve all symptoms. Humanity died out at 95% of the cure. Point-wise this tactics is not the best, I got around 10000p, but if one could create a third wave as well, it may be possible to create the Perfect Plague with ALL transmission, symptoms and abilties maxed out!

    • Markham Asylum

      Very cool idea, Don. Nice work!

      • DonJacobo

        Thanks a lot! I think this tactic adds a new dimension to the endgame. There is still much room for improving this way of playing. I still have to figure out which attibutes that delay the cure and which that reduce the researched percentage.

        Thanks for a great guide page!

        • Markham Asylum

          Groovy. If you ever hit that third wave, be sure to let us know.

          Thanks, I’m glad you find this guide useful.

          • PlagueMakuta

            I just read your “second wave” tactic and I figured out how to do a third wave. So you do the same thing, execpt as soon as the cure is done, finish all the drug resistance abilites and make it lethal, but not too much and get necrosis. Then when a news says that the last few humans lay dying in holes, devolve all drug resastinces and make it as leathal as possible. I got around 20,000 points (18,342 to be exact).

            • Markham Asylum

              Thanks for all the tips, Makuta. You’ve dropped some great contributions!

              • PlagueMakuta

                Thanks, Man.

                • TheEpicGuy

                  If possible, name it MegaFarts;
                  MegaFarts is spreading.
                  Thousands of people are infected with MegaFarts.
                  xD

                  • Markham Asylum

                    That’s a good one as well. See up higher in the comments for some additional juvenile-fun names.

  • Ryan

    Someone mentioned earlier th lack of effectiveness of popping the blue cure bubbles. This is a easy way for the game to be improved. Give real bonuses for fast clicks and when you hit a blue cure bubble make it have a real impact! I’ve got a number of other things I’d like to see.
    http://www.plaguetips.com/2012/06/ten-things-for-next-plague-inc-update.html

    • Markham Asylum

      Zombies would be cool.

      • Ryan

        Zombies are coming…and soon!

  • anonymous guy

    hey, I really wanna know how can I unlock the special plagues: u newd to buy them or u can unlock it normally by beating levels? thanks

    • Markham Asylum

      Yo anonymous guy, in order to unlock each new type of disease, you just need to beat the prior one on Normal or Brutal. You can practice on Casual if you like, but that won’t help with unlocking diseases.

      • PlagueMakuta

        In order to unlock special plagues, though, you have to beat all the plagues on brutal.

  • Chase

    Watch what happens when you fully upgrade insect and blood. It helps out a bunch.

    • Markham Asylum

      Indeed. The upgrade benefits noted above can be useful in the right situation.

  • BJ

    There are more combos mentioned in the achievements that aren’t here:

    Pubic Defacation
    Profuse Bleeding
    Swineflu Combo

    I will look into how these are found.

    • Markham Asylum

      Nice catch. Thanks, BJ.

      Looks like tomtortoise found one (see below).

      • PlagueMakuta

        haemophillea + skin leasions = profuse bleeding

  • tomtortoise

    Be careful: Diarrhea and insanity gives Public Defecation symptom combo which increases cure development

    • Markham Asylum

      Groovy. Thanks, man.

  • Kukka

    I hate how slowly those DNA and biohazard bubbles appear… I usually can collect just about 20 DNA points from them and in same time the cure goes from 0 to 100%

    Not much a change to evolve any higher lvl abilities, any tip how to make those bubbles pop-up more often? :P

    • Markham Asylum

      A DNA bubble should pop up each time a few country is infected, so you should get a ton of them throughout the course of the game. Unless you’re using the Parasite disease type, in which case you’ll won’t get them from new countries.

      Outside of that, I’m not sure when they come up.

      • Franny

        I found that the key to the parasite level is to not evolve the parasite special function at all. (the one that makes people unaware of host/symptoms). As long as you don’t evolve that, you will continue to get DNA points for each infected country, and many more points than usual from the orange DNA bubbles.

        • Markham Asylum

          Nice! Thanks, Franny.

    • Rodders

      The more scary the plague is, the more DNA you’ll get per bubble pop. This is easy on parasite as you can evolve the not being noticed ability with some symptoms.

      I tend to go Coughing -> Sneezing – it makes the plague more severe as well as increasing infection rates. Also get insomnia + Haemophilia as it decreases cure research speed fairly drastically.

  • Anonymous

    For some reason when I get to ‘Name Your Disease’ it won’t let me move on. Anything I can do about that?

    • Markham Asylum

      If you’ve actually tapped on “Disease Name”, typed in a name, hit Done, and then tapped on the arrow, and it still doesn’t work, then try closing all other running apps. If that still doesn’t help, delete it from your device and download it again or re-copy it from iTunes if you have it on a separate computer. If all that doesn’t help, contact Ndemic and ask for advice.

      Please let us know how it goes!

  • Mike Y.

    Maybe it’s a good idea to note that:
    Genetic Hardening decreases FUTURE research speed,
    While Genetic Reshuffle decreases the research ALREADY made.

    I have found it much more effective to get Genetic hardening when the cure completion percentage is relatively low (because there’s a lot of FUTURE research to be made), while genetic reshuffle is more effective when the cure completion percentage is high (because there already is a lot of research ALREADY made).

    Thanks for reading, and I hope you note this :D.

    • Markham Asylum

      Good distinction! This has been noted in the guide. Thanks, Mike.

  • Michael

    i finished the game on brutal
    most of the time i started in china
    but i cant figure out how to nuke russia and korea
    also infecting the space mossion
    please help

    • Markham Asylum

      Hey Michael, there’s info above in the comments about nukes and space missions. Let me know if it doesn’t help.

      • Michael

        thanks for the pointer it helped a bunch

        • Markham Asylum

          Awesome!

          • Kid rocks

            Space mission?? What’s that

            • Markham Asylum

              Read above.

  • Mikey

    Hey guys great tips! They help a bunch.
    Ill take a poll… WHAT IS YOUR FAVORITE DISEASE TYPE OVERALL?

    • Markham Asylum

      Cool idea on taking a Poll, Mikey. I’ll refrain from answering so as not to influence anyone, but I’m curious to see what people think.

    • Anonymous

      Virus… Because it forces you to play the game with symptoms, the way I presume the developer intended, IMHO

    • PlagueMakuta

      Nano-Virus

      I found this game challenging and fun, but on casual I could go through it pretty easily, and Nano-Virus was by far the hardest and most strategic part.
      P.S. Sorry I haven’t updated in a while… I got busy with Dragonvale, another great game .
      Oh, and add me on GameCenter: Makozapper

  • Anonymous

    choose a cool name like Bio-X-13

    • Markham Asylum

      Rock on with your bad self, Anonymous.

  • Mhy

    I choose fuckerrr on my viruses…lol… “fuckerr awareness day”..lol…i stayed late at night to unlock all the plague..im on bio weapon now….!!..this game was awesome..any more ideas to kill humanity?

    • Markham Asylum

      Hey Mhy, glad you’re enjoying it. I think this guide pretty much covers it, but if you discover any new strategies, please share.

  • Stuck

    Im on the Fungus round and I can never fully infect Greenland. I occasionally am able to infect Greenland, but the infection stops at aroud 7-9 people. I can never spread more than that…any ideas?

    • Markham Asylum

      Greenland is very cold; it and Iceland actually have the opposite climates of what you’d expect from their names. Combine that with the Fungus being bad at transmission and you’re definitely going to need Cold Resistance for Greenland.

      For Fungus in general, going for Cold/Heat and eventually Environmental Hardening is very helpful.

      • Anonymous

        If you use greenland as your starting point it will give you cold resistance and you will only have to worry about getting heat resistance later on.

        • Markham Asylum

          Nice one!

        • Franny

          Same thing applies if you start in a hot country… You will only need to do cold resistance.

          • Markham Asylum

            Good call, thanks for pointing that out.

  • IanXO4

    Here are some details about the symptoms in the game:

    There is a system of “inflation,” where the the cost to evolve a symptom increases by 1 DNA point for each time that you’ve previously “purchased” a symptom. For example, nausea will cost 2 DNA points if you’ve made no other purchases, but it will cost 12 DNA points if you’ve made 10 previous purchases. Mutations don’t count toward inflation, so if you’ve made no other purchases and get coughing by mutation, you can get sneezing for 5 DNA points.

    Syntax:
    name = base DNA points, infectivity, severity, lethality

    nothing = 0, 4, 1, 0

    nausea = -2, 1, 1, 0
    vomiting = -3, 3, 1, 0
    diarrhoea = -6, 6, 4, 1
    dysentery = -19, 8, 15, 8

    *coughing = -4, 3, 1, 0
    *pneumonia = -3, 3, 2, 0
    *sneezing = -5, 5, 1, 0
    pulmonary oedema = -7, 5, 4, 2
    pulmonary fiberosis = -6, 3, 3, 2
    immune suppression = -12, 2, 6, 4
    total organ failure = -28, 0, 20, 25

    Infectious series:
    *rash = -3, 2, 1, 0
    *sweating = -3, 2, 1, 0
    fever = -9, 4, 3, 3
    *skin lesions = -8, 11, 4, 0
    necrosis = -27, 10, 20, 13

    Severe series 1:
    insomnia = -2, 0, 3, 0
    paranoia = -4, 0, 4, 0
    seizures = -4, 1, 7, 3
    insanity = -18, 6, 15, 0

    Severe series 2:
    hyper sensitivity = -2, 1, 2, 0
    inflammation = -5, 2, 2, 2
    paralysis = -10, 1, 5, 1
    coma = -21, 0, 15, 2

    cysts = -2, 2, 2, 0
    abscesses = -2, 4, 4, 0
    tumours = -11, 2, 0, 4
    systemic infection = -17, 6, 7, 6

    anaemia = -2, 1, 1, 0
    haemophilia = -3, 4, 3, 0
    internal hemorrhaging = -12, 0, 9, 7
    hemorrhagic shock = -23, 0, 15, 15

    Some things to note:
    1) Total organ failure is the most deadly symptom by far.
    2) Necrosis is great for killing while remaining infectious.
    3) Symptoms marked with * are particularly good at spreading infection with limited severity.

    • Markham Asylum

      Ian, you are amazing. I’ve created the “Symptom Statistics” section based on this. Thanks so much!

      • IanXO4

        No problem. Thanks for putting together such a nice guide. I’m happy to contribute to it. I’m gathering other stats too. For now, here’s are the stats on symptom combos:

        projectile vomiting = 0, 4, 1, 0
        profuse bleeding = 0, 4, 4, 2
        public defectation = 0, 2, 0, 0
        walking dead = 0, 0, 0, 0
        swineflu = 0, ?, ?, ?

        System combos are not reversible, even if you devolve the symptoms that led to them.

        Note that walking dead still slows cure research; it’s just that it doesnt do anything else.

        I’m trying to get the swineflu combo so I can gather stats on it, but it doesnt seem to come often.

  • IanXO4

    Here are the stats on the amount of research required for the cure:

    You start a game with the base level of research that is required for the cure (19m for brutal, 25m for normal). The amount of research required to achieve the cure is then modified based on the symptoms and abilities you gain:

    Symptoms (% of base):
    insomnia = +3%
    paranoia = +6%
    insanity = +20%
    paralysis = +10%
    coma = +24%
    total organ failure = +0%
    any other symptom = +1%

    Abilities (% of base):
    genetic reshuffle 1 = +25%
    genetic reshuffle 2 = +25%
    genetic reshuffle 3 = +25%

  • IanXO4

    “Infectivity” is used in the game to describe how easily the disease spreads from person to person within a country.

    “Transmission” refers the ability for the disease to spread from country to country. Nonetheless, enhancing “transmission” traits will also enhance the “infectivity.” The stats for this are listed below.

    Transmission traits also have an inflation system, where the cost of a transmission trait increases by 1 DNA pt for each prior transmission trait you’ve obtained.

    name = base DNA pts, infectivity

    bird 1 = -12, 3
    bird 2 = -18, 6
    rodent 1 = -10, 3
    rodent 2 = -16, 6
    livestock 1 = -7, 2
    livestock 2 = -12, 4
    extreme zoonosis = -22, 5

    insect 1 = -9, 4
    insect 2 = -20, 8
    blood 1 = -8, 2
    blood 2 = -13, 4
    extreme hemotophagy = -24, 5

    air 1 = -9, 4
    air 2 = -14, 7
    water 1 = -9, 4
    water 2 = -15, 8
    extreme bioaerosol = -16, 5

    Early in the game, it is generally cheaper to enhance infectivity with symptoms than with transmission traits. Note that insect 1&2, air 1&2, and water 1&2 are generally more cost effective than other traits with respect to infectivity.

  • IanXO4

    Here are the base DNA points for Abilities, which also have inflation:

    cold resistance 1 = -7
    cold resistance 2 = -12
    heat resistance 1 = -11
    heat resistance 2 = -22
    environmental hardening = -30
    drug resistance 1 = -11
    drug resistance 2 = -25
    genetic hardening 1 = -7
    genetic hardening 2 = -22
    genetic reshuffle 1 = -17
    genetic reshuffle 2 = -21
    genetic reshuffle 3 = -25

    Genetic hardening 1 slows research by 10%, which means the number of days to until the cure is increased by 11% (assuming no other changes).

    Genetic hardening 1&2 slows research by 40%, which means the number of days to until the cure is increased by 67% (assuming no other changes).

    As I mentioned earlier, each genetic reshuffle increases the amount of research required for a cure by 25%. This 25% corresponds to 4.75m in brutal mode, and 6.25m in normal mode.

    • Markham Asylum

      You are a god amongst mortal plague-developers, Ian. Your data is sick (pun intended) and an invaluable addition to this guide.

  • Jjbgoode

    Marriage, Mormonism, and Boredom are also fun names to use. Gives the popups a whole different meaning. I really wanted to use ‘Beiber Fever’…would make losing more fun, but they don’t allow that many characters. “Beiber Fever was eradicated”. Win.

    • Markham Asylum

      lol, nice ones JJ.

      • LapisChocolate

        I tried “Shit”, “LOVE”, “Obama”, and “Your mom”. I even tried the names of my friends XD Super awesome game

        • Anonymous

          I’ve found that “swag” is a funny one to use.

  • FatBob

    Hi, great set of tips, thanks.

    Do you have any tips for Brutal Nano Virus? Thats the last one I need and I just can’t do it at all, always cured before I can infect the planet and kill them

    • Markham Asylum

      Hey FatBob, sorry, I haven’t played on Brutal. Perhaps one of our other readers can give you some tips.

      However, from a hypothetical point of view, since Nano gives so many free upgrades, have you tried devolving the ones you don’t want to prevent it from being too lethal too quickly?

    • PlagueMakuta

      Play the same as bacteria, but get those key code fragments at just the right moments:
      34%, 47%, and 78% ( you can do the same percentage multple times)

  • LapisChocolate

    Hello there,
    I have kept playing the game on “Normal” in high hopes of getting Virus quickly. I am still stuck with bacteria. The thing is, I have already tried to infect the whole world, and it worked (once, and only once), but then I do not have enough DNA points to get Total Organ Failure. Can anyone help?

    (I’m not in a game right now so I can start a new one easily.)

    • Markham Asylum

      Hey Lapis, have you already tried the whole “devolve any mutations that aren’t related to Infectivity until the whole world is infected, then go for Lethality” strategy? It’s a proven winner. Also, readers have dropped a lot of great additional strategy in the comments above.

      • LapisChocolate

        Just completed it :D
        Btw now im stuck at virus -_- xD the “GO ALL ON TRANSMISSIONS” really work TYVM :)

        • Markham Asylum

          Awesome! Glad to help.

          Note that the virus may give you Severity and Lethality before you want it. You may need to manually devolve all the crazy mutations you get when playing with a virus.

          • LapisChocolate

            Got it. You are amazing. This guide is amazing! And you still manage to go on and monitor all the comments. That’s plain awesomeness :)

            Btw, it would be nice if you create a section under “Abilities” that is called “Special Abilities” which is specific to the plague type.
            Eg: Bacteria – Bacterial Shell (1-3)
            Virus – Viral Instability (1-3)

            Yeah :) Cheers, and keep up the good work!

            • Markham Asylum

              Thanks, Lapis. I’m glad you like the guide so much and have found it so useful.

              I’d be glad to add those plague-specific abilities, but unfortunately I don’t know them. If anyone has details on them, please share and get some recognition!

              • LapisChocolate

                Okay then. Here, this is very vague:
                Bacteria
                Bacterial Resistance 1,2,3
                Protects against all climates.

                Virus
                Viral Inststability 1,2,3
                Makes virus more unstable and mutates more rapidly

                Fungus
                Spore burst 1-? -> spore eruption
                Spore burst: Burst spores to infect small islands, etc
                Spore eruption: bursts heck loads of spores to infect more countries

                Parasite
                Symbiotic Relationship (something to do with symbiosis) 1,2,3
                Helps to hide in the body and get less unnoticed. I think it also kinda affects the host.

                Prion
                Can’t remember. Will update later

                Nanobot
                Intercept Code Fragments -> intercept code segments -> overload virus replicators

                will update rest at a later date :)

                • Markham Asylum

                  Nice, thanks Lapis. I updated the guide with info on Bacteria, Virus, and Fungus abilities, since your comment was pretty specific on those. If you can get complete info on the others, please share!

                  • LapisChocolate

                    Right. So i think my fungus one is kinda glitched. Anyway, i see that it is evolve 6x Spore Burst to evolve Spore Eruption.

                    Parasite’s Symbiosis helps to stay undetected. Stuff like that.

                    Prion:
                    Neural Atrophy 1,2,3.
                    Destroy brain cells to make simple tasks harder.

                    Got exams coming, gonna update in 2 months or more. Sorry

                    • Markham Asylum

                      Spore stuff updated. Thanks, Lapis!

                      If you get more info on Neural Atrophy, please share.

                      Best wishes for those exams.

    • Anonymous

      The way that worked for me was putting into transmissions and the upgrading the bacteria and putting one into drug resistance and one or two into cold but holding off on symptoms and if it mutates then devolve it and then once the whole world is infected then devolve all transmissions and the cold resistances and put everything into symptoms I chose starting with coughing and branching to total organ failure and coma and paralyze took me a little bit but worked I named it Bob

  • oilman

    Hi there,
    how to get contaminated pack achievemets ?

    • Markham Asylum

      Hey oilman, I’m not sure on that one. Anybody gotten this?

  • oilman

    I just found out the swineflu combo, you need:
    Extreme Zoonosis (bird, rat & sheet combined ability)
    nausea, vomiting, diarrhoea,
    coughing, pneumonia,
    sneezing, fever,
    insomnia, inflammation,
    drug resistance 1, 2
    and [genetic upgrades] to keep time only
    devolve all others and wait.
    that how i got it.

    • Markham Asylum

      Thanks, oilman. Info added to the guide.

      • Cadogan

        I just got the swine flu combo and did not have inflammation as a symptom, so that can be eliminated. And the combo said that doctors were “wasting their time trying to find a cure for the swine flu,” so I assume that means that research is slowed.

        • Markham Asylum

          Thanks for the tip, Cadogan.

          • Bwrabbitgirl

            Swine Flu does not need fever.
            I only had Nausea, Vomiting, Diarrhea, Pneumonia, Coughing, Insomnia, Paranoia, and Anemia.

            • Markham Asylum

              Updated. Thanks!

  • UGA1998

    Swineflu combo: Livestock 2 & Coughing or Livestock 2 & Sneezing. I usually activate Coughing then Livestock 2 then Sneezing. I get the combo pretty consistently with this technique. I believe it is only Livestock 2 & Coughing.

    • Markham Asylum

      Awesome. Thanks, UGA!

  • Kusanagi

    I think you switched the swineflu and walking dead combo in the guide. As it states now that the walking dead is livestock 2 % coughigh and swineflu is the one with insomnia. I thought it should have been the other way around.

    • Markham Asylum

      I sure did. Fixed; thanks Kusanagi!

      Thanks for comments below as well; I’ll get to them, but maybe not today.

    • Gastryp

      The walking dead syndrome its justa anemia and insomnia (people tired and pale) slows down research cuz of tired scientist

      • Markham Asylum

        Thanks Gastryp, but that’s what’s already listed…

  • Kusanagi

    I saw that there was no information on the symbiosis ability yet so i did some testing, this might be usefull to know. Symbiosis 1 reduces severity by 4 points.

    I tested it by adding coughing, sneezing and cysts. They added 1 point, 1 point and 2 points respectively bringing the total to 5. Then adding symbiosis 1 reduced severity back to 1. The numbers were taking from the Disease Graph under Data.

    Will get more info in an hour or so regarding symbiosis 2 & 3

    • Kusanagi

      My apologies for 3 posts in a row. Symbiosis 2 reduces severity by 8 points does not seem to increase infectivity. Symbiosis 3 reduces severity by 10 points and increases infectivity by 2.

      To put it in reader friendly format:

      Ability (cost,infectivity,severity,lethality)

      Symbiosis 1= (-3, 0, -4, 0)
      Symbiosis 2= (-6, 0, -8, 0)
      Symbiosis 3= (-8, 2, -10, 0)

      I hope this info is helpfull :)

      ps. Cost not counting inflation.
      pps. It seems that on the parasite level you get more DNA points per orange bubble, for example i get 6 quite often and never got just 1 point even though that is quite common on the other diseases (bacteria, fungus etc.)

      • Markham Asylum

        Excellent. Thanks, Kusanagi!

  • john smith

    I have gotten s flu inthe past on all its take more time for the cure. It is weaken I system and something else.

    • Markham Asylum

      Thanks john, but we already have Swine Flu listed. Do you perhaps know its statistics?

  • Oli the plague

    Swine flu makes the cure longer

    • Markham Asylum

      Thanks Oli, but that’s already listed.

  • oli the plague

    gene compression 1,2,3 make resets the leathal bar and slightly makes it slower to regain lethality

    deactivate genes 1,2,3 should make it longer to become lethal

    Nucleic Acid Neutralization 1,2,3 will drop the lethal bar back and make it slowdown lethality

    gene compression 3+ deactivate genes 3 + NAN 3 will make it unlock: unlease Armageddon gene

    unlock Armageddon gene will make the lethal bar to max (lethality+++) and make the infectivity and severity bar to half way making it extremly dangerous and worse than total organ faliure.

    thanks if you have this than its ok
    -oli

    • oli the plague

      if you want i can try nano virus but why do i have to the hard diesease types :D

      • oli the plague

        btw thats the bio weapon ablilitys ^^^^^^^

    • Markham Asylum

      Thanks, oli, this is good info. It’ll be a while before I get a chance to update the guide, but I definitely will.

  • Joeitus

    If you name your plague ‘Erections’ you get some funny messages lol

    • Markham Asylum

      Agreed. Dick jokes are always in fashion.

  • John Smith

    You get the nuke US to china by a random you have stay under the off the map long for it take effect

    • Markham Asylum

      Thanks, John, but can you be more specific?

    • oli the plague

      you can make the US president ill by making it a bit lethal and highly infective with drug resistance 2

      • Anonymous

        Idk about china but I do know its not completely random. I can consistently get Russia
        By getting blood 1 and 2 for transmission and only that. Btw this is on the immune cheat. Then get drug resist 1&2 and start in a hot country so cold1 then I get symptoms that spread the disease and get severity to just below halfway. Keep lethality at almost none to very low. Wait…. A lot. Eventually the president will be taken ill. Get insanity. Spain will get elected. Get the severity up as high as you can without making it much more lethal. So no necrosis or anything like that. She will nuke Russia after you get the threatened Russia MSG.

  • Juan

    Hello, I have been playing this game for more than 3 months and havent been able to pass the bacteria stage. Ive tried almost all the countries and many different types of attacks on normal. Can anyone tell me how they got passed the bacteria stage? Im getting tired of it. Let me know what country you picked and how you went along with your disease. thankyou

    • Markham Asylum

      Hey Juan, have you already tried the whole “devolve any mutations that aren’t related to Infectivity until the whole world is infected, then go for Lethality” strategy? It’s a proven winner. Also, readers have dropped a lot of great additional strategy in the comments above.

      • oli the plague

        i also agree with mark, dont get any symptoms and just get air 2 and water 2, then when you infectd everyone make the plague super lethal

        • oli the plague

          you can use this stratergy on bacteria, prion, parasite, and fungus only ☢

          • Me

            Start in russia and get water 1&2 or start in saudi arabia and get air 1&2 DEVOLVE ALL SYMPTOMS EXCEPT FOR COUGHING UNTIL EVERYBODY IN THE WORLD IS INFECTED THEN DEVOLVE ALL TRANSMISSION UPGRADES AND BUY PNEUMONIA PULMANARY FIBROSIS AND TOTAL ORGAN FAILURE, then buy coma, then paralysis inflammation seizures and insanity

  • oilman

    has anyone got the message about (some country) bombs infected cities ?
    and that country lose over 60% from it’s population ?
    i only got it by using incurable cheat and just waiting (i want to check what could happened after along time pass after been discovered)

    • oli the plague

      i think you need to make the plague slightly leathal, very scary ish and yeah i guess thats it

  • RockieOnly

    Hey does anyone have any stratiges to get highscores? The most I can get is 10s of thousands but on the highscores list in the app they are all in the 10s of millions. And one guy that always has a score of 2122209408. How are these people getting such huge scores? Any ideas?

    • RockieOnly

      Sorry for the double post but I forgot to add, does anyone even know how the scoring system even works? What is worth what and what not?

      • Anonymous

        They have got to be cheating. Probably using jail broken phones.

      • UGA1998

        From the best I can tell it is a combination of:
        Quickness (days)
        Cure Percentage Rate
        Strength of Plague (infectivity, severity, and lethality)

        I tracked this for a while and came up with these scores:
        (The first number in the series is infectivity, then severity, lethality, days, cure percentage and finally score

        (91,113,91,1075,8%)    122,740 5 star “biohazard symbol” plague
        (118,93,87,785,51%)  18,170 3 star plague
        (95,83,90,947,79%) 10,140
        (92,126,57,449,53%)   29,750 3 star plague
        (60,91,89,772,10%) 80,690 4 star plague
        (84,92,84,722,19%)   43,440 4 star plague
        (91,102,91,626,10%)  103,410 5 star plague
        (110,100,94,596,22%) 44,350 4 star plague
        (86,95,89,932,5%)    190,600 5 star plague
        (94,103,89,1405,8%) 99,350 4 star plague

        I haven’t analyzed these numbers to see how a score is derived and there may be other factors I haven’t considered, but I think this is pretty close. I’ve also noticed if you disable symptoms at the end of the game to get enough DNA points to buy something else, you seem to get penalized in the final score.

        • TO_Asylum

          Thanks for posting the data. A quick regression suggests the biggest effect comes from cure, or more specifically inverse of cure. The correlation between 1/cure and score is in the high 90s, i.e., that explains all the variation. The other variables (were not statistically significant, in this set at least. Do you recall what difficulty and plague type these were? I ask because I noted the same strategy played out in casual vs normal resulted in a significant difference.

  • UGA1998

    Worked through the Swine Flu “symptom” combo and got it worked out. I was incorrect in a previous post stating it was livestock 2 and coughing. It is actually a list of symptoms that mirror the swine flu. 1. Nausea 2. Pneumonia 3. Vomiting 4. Vomiting 5. Diarrhea 6. Coughing 7. Sneezing 8. Fever 9. Insomnia 10. Paranoia

    You also need Livestock 1 & 2. It is a lot of work for not a lot of results. It works like a tiny genetic shuffle and typically comes very late in the game and is totally unreliable. It causes an additional 2.25m in brutal mode of research. The cure went from 99% to 96%. Not a very big deal. I also can’t tell if the walking dead combo does anything at all. No stat is affected.

    Other Tips:
    1: The higher your severity and infectivity – The higher your DNA points for infecting other countries.
    Example: Coughing = 1 pt for each country, Coughing & Sneezing = 2pts. The points get higher, but I am not sure how much. I have seen 6pts per infected country

    2: Countries have a limit of severity until your plague is detected. This means you can let Symptoms mutate and just leave them until that countries tolerance level is closing in. I gauge this based on the infected rate of the host country. You can usually run with coughing and sneezing to about 90%. You will have to cancel one symptom. All this time you will get accelerated points for infecting new countries. Once cancelled you go back to earning 1 point per country.

    What if you start in a country like United States who has a large population and high drug capabilies to keep your infection rates down? They don’t keep your transmission rates down!

    This has worked great for me as I scored 190,000 today. This has been a great site and helped me refine strategy so I am happy to share. You get large points for holding the cure under 10%. 6% will pay 190,000 points.

    The shame is I don’t know how this compares because there are so many people with 20 million points. I would like to know what the true high scores are so I know what is attainable. I don’t think there is anything that can be done to sort this out in game center leader boards.

    Does anyone have a concise way to explain the nuclear objectives? I cannot get them.

    • oli the plague

      swine flu + frug resistencd is a good way of making the us president infected

      • UGA1998

        Interesting. I have heard when this happens you can quickly enable seizures and then insanity, but disable seizures so just insanity is left and Palin gets voted in. Some people think this is the way to the nukes.

  • Amy

    I named my disease Bieberfever. NEWS: Thousands are infected with Bieberfever

    • Markham Asylum

      That’s pretty good, Amy. But you’re trying to wipe out everyone, not just teenage girls. ;-)

      • Amy

        Haha very true:)

        • oli the plague

          i name my plague gods revenge

  • Oli the plague

    What is so good boutb palin getting voted?
    Ps sweating makes apple icure touch break

    • Oli the plague

      Name in orange here I come! Look how much I helped ^^^^^^^^

      • Markham Asylum

        Yup, you’ll get it for sure. I should finally have a chance to update this weekend.

      • Markham Asylum

        After tallying everything, you don’t quite have orange status yet. However, if you can get info on those Nano-Virus abilities… :-)

        • oli the plague

          the nano virus will and should tke longer to figure out than bio weapon abiliys
          all i know is drug resistance 1 2 unlocks drug imunity which makes it more infective in rich countrys and makes it just as infective as poor countrys

          • Markham Asylum

            Awesome. If you get the full info, be sure to post it up!

  • UGA1998

    5 Star Plague Strategy

    (This Strategy will get you a huge score if you master it. 100,000+)
    -strategy uses bioweapon, which is unpredictable so it may take many attempts to get it right (sometimes the weapon can become very lethal too quickly so might want to bail on these games and start another round)
    -This strategy takes a very long time. Not the way I originally started playing so you will want to know when to fast forward and when not to.
    -please share your highest score using this strategy or if you are able to refine it and score more, please let everyone know the tweaks. My best is 190,000. If you tweak the disease and score more, let everyone know how you did it.

    1. Get gene compression 1,2,3
    2. (be prepared to get Deactivate Modified Genes 1,2,3 anytime the disease becomes lethal. Only three chances to set it back. It’s best to have the disease get lethal later in the game because it really cripples your game if your spending early game points on it)
    3. Get Bird 1
    4. Get Insomnia
    5. Get Air 1
    6. Get Paranoia either through purchase or mutation
    6. Get Water 1
    7. Countries will begin getting infected. You will 2 or 3 DNA points for each country with insomnia and paranoia. Your severity is pretty high so you have to watch the United States infectivity percentage. You will need to drop Paranoia around 40%. Drop Insomnia around 60%. Just buy coughing after this happens. You can have sneezing, but just devolve coughing so there is only 1 active symptom. you can wait on sneezing to mutate. Devolve all mutating symptoms from this point.
    8. We have used the US strong drug capability against the world. Makes for a slow game, but who cares. You can infect about 1/2 all countries during this phase. After this you will only earn 1 point per country.
    9. While you are infect countries Bird 2
    10. Heat Resistance 1
    11. Cold Resistance 1
    12. Drug Resistance 1 (not until you are done getting points as described earlier)
    13. Get Nucleic Acid Neutralization 1,2,3
    14. That’s about it for spending right now. Just pool your points and hope the whole is infected before the disease becomes lethal.
    15. You should have 70-120 DNA points now. The world is infected. What next? I like to wait for the disease to become lethal for the final time. It will kill off 6mil before starting cure, which will allow you quicker accumulation of DNA points for taking the population down.
    16. Get Armaggedon (special ability of bioweapon that appears when you get gene compression 1-3, deactivate modified gene 1-3, and Nucleic acid neutralization 1-3.
    17. From Sneezing get Immune Suppression
    18. Total Organ Failure
    19. Coma (you are probably about out of points now, you will have to wait for disease to start killing to get more)
    20. Paralysis
    21. Inflamation
    22. Insanity
    23. Paranoia and Insomnia
    24. Spend extra if you have it on whatever. You won’t have many more points.
    25. Goal is to keep cure under 10%. Do this and you should score more than 100,000 points and get a 5 star (biohazard) plague. Don’t be surprised if you game lasts 1000 days.

    • Markham Asylum

      You’ve made some great contributions to this guide, UGA. Many thanks.

      • UGA1998

        No Problem! Here are the stats on Swine Flu. Infectivity, lethality, Severity = 0. 10% increase in budget required similiar to the way a symptom like seizures would work.

        • oli the plague

          wow uga your ;like a robot built for this game! and sorry for the disjointed posts

        • Markham Asylum

          Thanks. I’ve added a note about the 10% thing.

  • oli the plague

    great job on the bio weapon abilitys, i know there prices

    nan, gc and dmg 1 cost 1 dna
    nan gc and dmg 2 cost 2 dna
    nan gc and dmg 3 cost 3 dna i thought 2 and 3 where more but i did some maths.
    these are without any other abilitys
    armadon gene costs 11 i think

    good luck il have the country details soon!

    • Markham Asylum

      Ooh, country details, great call. That would be excellent info to add to this guide.

  • oli the plague

    i need hints and walkthrough on bioweapon on brutal to get all cheat plagues
    ps anyone have those cheats yet

  • oli the plague

    the game makers over exaggerated the diesease types

    bacteria is ok
    virus is ok
    fungus hard to travel OH whats this button here SPORE BURST boom!
    parasite get real theres dna everywhere
    prion is ok
    nanovirus has a completely different “kill” switch that i expected
    bio weapon kills everything umm no thanks i have tons of infected not dead people

    • Theman

      Actually, prions are proteins and there have no DNA

      • Theman

        Also, because of this, they are uncureable.

  • oli the plague

    just tell me if im posting to mush stuff and il stop

    the nanovirus because its already being cured, coma and paralysis are super cheap to stop the cure

    • Markham Asylum

      oli, you’re welcome to post as much as you want, though most of your info is pretty disjointed. I generally only update the guide with comment info that is cohesive.

  • oli the plague

    i dont know if this post is off or disjointed but this is how i think of the sympotom chart

    transmition infectivity transimtion/infectivity
    (nausea side) ( coughing side) (rash)

    severity transition/severity lethality
    ( insonia) (cysts) (after animia

    • oli the plague

      that didnt go as planed
      transition(nausea), infectivity(cough), transition,infectivity (rash)
      severity(insonia), severity/transmition (cysts) i goto go but this is the sides of what side does what to your diesease\

      • Markham Asylum

        Sorry oli, I’m not sure what you’re going for here. If you want to share some info that you think I would add to the guide, just take your time in organizing it. :-)

        • oli the plague

          yeah il have country stuff shortly

  • http://www.google.com/en wfean

    Helpful. Will defintely be back

    • Markham Asylum

      Right on.

  • Aethyr

    Great job with the site, it gave me a lot of useful info. And, from reading the comments above, I thought of a great name for the plague. “Charities are holding a Jesus awareness day.”

    • Markham Asylum

      Thanks, Aethyr. I’m glad you enjoy it so much.

  • Dr. D

    So I’ve managed to get the US President ill, and Palin elected in record time for how many times I’ve attempted the Nuke achievement. I did this by starting in China, getting China completely infected and waiting for the US to get a few hundred infected. Then, I made it slightly noticeable (coughing and sneezing). Once the POTUS was ill, I evolved Insanity and devolved the seizures and paranoia. Palin gets elected. I put evolved paranoia again, and then evolved the swine flu combo. STILL NO LUCK! Apparently the developers are working on including more “breadcrumbs” in the next update. BUT they have stated that while there IS some randomness to it, you CAN get it. The achievement does exist but is very difficult to get. lol

    • Markham Asylum

      Nice work, Dr. D. If you find out for sure, please let us know!

  • Oli the plague

    Hang on bio weapon costs are 1 then3 then 5
    For the abilitys

    • Markham Asylum

      The cost info is kind of useful, but since everything goes up with each purchase, it’s not likely to be relevant by the time someone is ready to buy a disease-specific ability.

  • Aethyr

    Hey, I am having trouble with Nano Virus on brutal. Anyone help?

    • oli the plague

      i did it you start in china get and get extreme zoonosis and drug resistance 1,2 and imunity
      and keep getting the interceptors also get pyralisis and other infective symptoms, then when half way through get coma and other cure defence syptoms , at the end get total organ failure

  • oli the plague

    found out an important tip when scientists increase understanding of a symptom like inflamatation if you have other symptoms around it, it will mutate without any warning so check your symptoms chart after you get a notice like that

    • Markham Asylum

      Good one, oli; it’s been added.

      You’re certainly close to getting your name in orange. The country info you mentioned would cinch it for sure.

      • oli the plague

        yeah im sorry its taking forever i dont usally have much time

  • Derp

    I simply cannot seem to beat the game at all, hell, I’ve even used some money to get virus and fungus… I infect the entire planet, start evolving a specific tree. Then they start the cure, and I cannot get reshuffle before it at 100% and I’ve only killed off about 10% of the world population… Even when I had 79 DNA points I only managed to get to paranoia and they all magically disappeared… Not to mention I miss the PC version which used to have a secondary cure outcome where the cure has an undesired effect and instead it strengthens your disease even further. Any help?

    • Derpy

      Btw how many points do I need to go up to total organ failure and coma?

      • oli the plague

        if you read the guidl it will tell the cost derpy but for bacteria fungus prion and parasite there is a cheat to not get any symptoms until you infect everyone then go for total organ stuff up

  • Derpy

    I am also excited for the upcoming neurax worm. It is a worm that burrows into the hosts brain and takes control of their bodies.

    • oli the plague

      isnt that prion

      • Derpy

        If you check the IGN page (I think) it says that the neural worm is coming with the next update along with new graphics and better AI

  • Chronic one

    Hey I’ve run into an impasse…I get to like 375,000 people left uninfected and then I can’t infect anymore, it’s usually like greenland and Iceland that survive. How do I overcome this? I used Felix’s strategy of air and water transmission

    • Anonymous

      Cold Resistance 1 and possibly 2.

      • UGA1998

        Livestock 1 and/or 2 will help infect Greenland also. Without Cold 1&2 it takes forever to infect Greenland. Try Cold 1&2 with livestock 1. If this doesn’t do it add Livestock 2.

        You will need more if you are starting from a HOT country. (Saudi Arabia, India, Brazil, etc.). Less from a even climate country (USA, China, Japan). Not much at all from a cold climate (Russia, Canada, etc.). You can infect any country with enough time even with no resistance. It would probably take 10 years, but you could. It all depends on how quickly you need to infect the world as to how much transmission, infectivity, and resistance you add to your disease.

        Here are some good guidelines for infecting Greenland within a reasonable amount of time based on different countries of origin. (at a minimum)

        Hot (Saudia Arabia): Cold 1&2, Water 1&2, Air 1, Drug 1, Livestock 1. (probably want Air 2 and Drug 2 also)

        Neutral Climate (China): Cold 1, Water 1, Air 1, Drug 1, Livestock 1. (probably want cold 2, drug 2)

        Cold (Russia): Cold 1, Water 1, Livestock 1 (probably want drug 1, air 1)

        Other Notes:
        1. Greenland only infected by ship from Iceland, Russia or Finland. (maybe a few other countries like Dennark, etc.)
        2. Drug Resitance needed to infect most of these countries like Finland etc.
        3. If you choose to start from a Neutral country, you will need Hot & Cold abilities to infect Greenland & Africa.

        • Markham Asylum

          Thanks again, UGA. Greenland is definitely a bugger.

  • UGA1998

    Nano Virus Special Abilities
    1.  Code Fragment Interception
    -Works like a Genetic Hardening
    -10% increase to finding cure & +3 to infectivity
    - Cost is 3 points

    2.  Code Segment Interception
    -Works like Genetic Hardening 2
    -30% increase to finding cure
    -Cost is 5 points before inflation

    3.  Factory Replication Overload
    -Drastically increases infectivity for a short time (time period varies as does the infectivity increase). Infectivity +50 to +110
    -Once this time has expired the disease’s infectivity goes back to what it was, but with -5 Infectivity
    -Cost is 6 points before inflation

    1.  Radical Elements Stabilized
    -Works like a Genetic Reshuffle (on Steroids)
    -100% increase to find cure
    - Cost is 4 points

    2.  Encryption Breached
    -Same as Radical Elements Stabilized
    -100% increase to find cure
    -Cost is 9 points before inflation

    3.  Broadcast Interceptor Overload
    -  Temporary 200% increase to finding cure (about 3 weeks)
    - Once time is up the cure picks up where it left off
    ****Tip:  If you use this right before you win the game you can decrease the cure progress before it has a chance to reset and increase your score by a lot of points!  When there are about 500-5000 people still alive, activate this1
    -Cost is 6 Points before inflation (usually 19 – 22 points when you use it at the end of the game)

    • Markham Asylum

      Booyah! Added. Nice job.

  • http://nsf.4x86.com RushJet1

    If you get all the “Spore Burst” and both “Spore Eruption” abilities a new one will appear between them called “Spore Hardening,” which says “Hardens plague spores to survive in the air indefinitely. Spores continually released.” Currently costs me 23 DNA points with 15 upgrades purchased so don’t know if the “add one dna cost per upgrade” applies, or if it does, it’s just fairly low base-cost.

    • Markham Asylum

      Added! Thanks, and nice Mega Man reference with your Delta Attack name.

  • anwipe

    If you you don’t have auto-stop off, you can push the bubbles that pop-up when you get a alert!

    • Markham Asylum

      Added. Thanks, anwipe!

  • Oli the plague

    Government actions :D
    Exterminate pigeons; slows plague with bird upgrades
    Exterminate birds. Stops plague via bird transmittions
    Exterminate rats: slows plague via rodent
    Exterminate rodents: same as bird
    Distribute insect repelant: slow insect transmittions
    Insectid spraying campaign stop plague via insect
    Health care: idk prob slows plague generally
    Hot water bottle: stops infection via water drinking
    Face masks: stop coughing and sneezing ect and slows air infectivity
    Fallen government: stops cure for country
    Shuts boarders: stops cure from getting in or out via people
    Blood test: slow blood transits
    Cure research: speed cure
    Martinal law stops water transits
    Ban livestock movement: slows livestock transits
    Cull livestock: stops livestock transits
    Corp disposal: idk increase infectivity via necrosis
    Burn corps; stops transits via necrosis

    Tell me if I missed a action

    • Oli the plague

      Curfews will slow infectivity In general

    • Markham Asylum

      Awesome info; added. Congrats on finally getting your name in orange! Woot woot!

      • oli the plague

        thanks i will have info on the new neurax worm

  • oli the plague

    i have the ablilites of neurax worm drum roll!
    trojan planes 1: gives the plague ability to make a plane go where ever you want it to go
    trojan planes 2-3: increases likelyhood of trojan planes bubble
    trojan roamers 1-2-3: increases infectivity/severity: increases ability of transmittion by person to another country through land borders
    trojan destroyers 1-2-3: increase infectivity/severity: better likelyhood of infection to the country the trojan planes landed in
    next i will do the other special plagues info

    • Markham Asylum

      Updated! Thanks again, oli.

  • What the french toast

    HOW TO GET NUKE ACHIEVEMENTS…
    Start anywhere, get drug resistance 1&2. Make your plauge slightly leathal. When you get the president sick, get insanity. when you get Palin elected, get the paralyse symptom and Palin will nuke either Russia or China.(generals unable to stop her).
    May take a few years, be patient.

    • Markham Asylum

      Great! Thanks, WTFT.

      • Kendra.Clara

        worked perfectly! thank you!!!

    • zombrax

      She will only nuke russia this way, there must be other way for china

      • James

        I believe adding bird 2 causes her to nuke china and cold causes russia, I read somewhere else and tried avoiding cold, and added bird 2 and she threatened china. As my 1 time trying doesnt give a guarentee, I hope it helps.

  • Big Irms

    Neurax worm can be defeated through eradicating humanity or enslaving humanity. Countries that worship the worm will stopp all cure research.

    • Markham Asylum

      Added. Thanks, Big Irms!

  • FahrenheitBlack

    Oops Combo:
    Sneezing and Diarrhea
    Lowers Productivity and Increases Awareness

    • Markham Asylum

      Added! Thanks, FahrenheitBlack.

  • FahrenheitBlack

    Has anyone confirmed the above method for getting the nuke achievements?

  • What the french toast

    I have the achievements using this exact strategy. I couls send you a screenshot if you want.

  • What the french toast

    Plaugue in Space Achievement!!!
    Imunnity Cheat, start in USA 1.blood 1&2 2.air 1&2 3.water 1&2 4.extreme bio transmission 5.drug 1&2 6.insomnia 7.rash 8.sweating 9.skin legions 10.anaemia 11.haemophila 12. internal hem. 13President ill 14.seisures 15.insanity 16.Palin elected 17.When it says space mission planned devolve all symptoms EXCEPT insomnia, paranoia, and insanity 18.Space mission launch. 19. inflame 20. Space mission failure. Yay! Finally figured out Space achievement! (I got it at 2016 be PATIENT!!)

    • Markham Asylum

      Nice work!

    • Diplomacy tic

      Confirmed

  • Kaye

    Aftet the recent update it seems that bio-weapon is impossible to beat. Any tips? It’s become harder now, it’s seems that the developer doesn’t allow refunds for devolving it cost to devolve after you’ve reached a certain point.

    • oilman

      this is what i found out from Neurax worm
      TRANSMISSION:
      Concertina Locomotion
      =>Undulatory Locomotion(up)
      ==>air 1(up)
      ===>air 2(up)
      ====>air 3(up)
      ==>water 1(up right)
      ===>water 2(up right)
      ====>water 3(up right)(must have eggs 2)

      Eggs 1
      =>eggs 2(up)
      =>bird 1(down left)
      ==>bird 2(down left)
      =>insect 1(down)
      ==>insect 2(down)
      =>rodent 1(down right)
      ==>rodent 2(down right)

      Genetic Swap
      =>mutative regenration 1(down)
      ==>mutative regenration 2(down right)
      =>corpse feeder 1(up right)
      ==>corpse feeder 2(up)

      SYMPTOMS:
      Neural Breach
      =>Cerebral Tendrils(up)
      ==>Frontal Mesh(up)
      ===>Perceptive Jolt(up right)
      ====>Occipital Mesh(up right)
      ====>Perceptive Shift(up)
      ===>Immaturity(up left)
      ==>Confusion(up right)
      ===>Memory Loss(up right)
      ====>Aneurysm(up right)
      =====>Aphasia(up right)
      ======>Apraxia(down right)
      ======>Coma(up right)
      =======>Brain Haemorrhage(up)
      ==>Adrenergic Constriction(up left)
      ===>Anxiolytic Infusion(up left)
      ====>Psychosis(up left)
      =====>Deapair(down left)
      ======>Suicide(down)
      =====>Adortion(up)
      ======>Devotion(up)

      ABILITIES:
      Trojan Planes 1
      =>Trojan Planes 2(down right)
      ==>Trojan Planes 3(down right)
      ==>Trojan roamers 1(down)
      ===>Trojan roamers 2(down)
      ==>Trojan destroyers 1(up right)
      ===>Trojan destroyers 2(up right)

      • Oli the plague

        It should be easy to find the what the symptoms do because probably all of them just increase infectivity and from confusion down to coma or brain hemorrhage are cure defense also transcendence which was weirdly left out of the symptoms is severity +++

        -I also have the full neurax worm abilitys if you scroll up a bit :D

        • Big Irms

          An important thing to note is that some of the symptoms have a negative severity but you have to evolve positive severity symptoms first. It is possible to save up points, evolve multiple symptoms at the same time, and have them cancel out the severity effect. See post below.

    • Anonymous

      I know that feel bro

  • http://stu-in-flag.net stu-in-flag

    With respect to the NUKE ACHIEVEMENT:

    I have been able to replicate parts of the path outlined above.

    I start with Bacteria in Normal Mode, inflecting Indonesia (lots of flights and ships). I get Drug Resistance 1,2. Then I wait until the US is infected, downgrading all mutations.

    When the US is infected, I upgrade Coughing, Pneumonia and Pulmonary Edema. This adds slight lethality and considerable infectivity. This helps the spread of the disease, and get it noticed so the cure process starts. At this point I add Genetic Hardening 1,2.

    The President usually gets ill. If you add Insomnia, Paranoia, Seizures and Insanity, then Spalin occasionally becomes President. HOWEVER, when I add Inflammation and Paralysis, I have not been able to achievement the nuking of Russia or China because the cure happens too quickly. This is even with the addition of Genetic Reshuffling as point are available.

    It seems like other mutations and improvement prevent this from happening. For instance, it seems like adding Air 1 or Water 1 prevents the Presidents illness. So if ships our airplanes become cleaner, it takes forever for the disease to make it anywhere.

    So, I think French Toast is onto something, but it’s not the whole story.

    • What the french toast

      It takes a considerable amount of time before Palin treatenes Russia/China. Use the immune cheat if you have it unlocked

    • http://stu-in-flag.net stu-in-flag

      Same results with Prion. Seems like infecting India first helps with speed but still not a win.

      I am doing this without the use of cheats, which I believe the developer has indicated that all achievements are possible without cheating.

  • http://stu-in-flag.net stu-in-flag

    A couple corrolaries on the Nuke Achievement:

    If you get the warning about scientists increasing their understanding of Inflammation, you should probably bailout. You have to have Inflammation for the quickest path to Paralysis.

    If you get the Sterilization or Filtration warning before infecting the US, I recommend bailing out. While I could be wrong, it just takes forever to get to the US and seems like adding Air 1, or Water 1 eliminates the President getting ill.

    • Markham Asylum

      Interesting info, stu. Thanks for contributing your achievement knowledge.

      • Ninjawild

        one thing to point out..

        if you add symptoms further along in any given symptom tree, you can devolve earlier ones that you don’t need.. say for example, you add DNA points into Insomnia –> Paranoia –> Inflammation to get to Paralysis, you can then devolve the first three and still keep paralysis.. even if this tree of symptoms is the only symptoms you have put points into.. this works well if you’re trying to get to a certain symptom and don’t need another.. also, if you do not close the Disease menu while doing this, it doesn’t affect the world.. as if you never had put points into the devolved symptoms..

  • TofuCurry

    Hiya. I discovered what the Oops symptom combo was after messing around on unlimited plague. Turns out it’s sneezing and diarrhea. Hope that helps!

    • Markham Asylum

      Thanks, Tofu, but FahrenheitBlack beat you by 5 days. =o

      • TofuCurry

        Ok, then how about this; The Trojan Planes ability doesn’t enable the planes. It increases the chance. I’ve gotten planes without it unlocked. =D

        • Markham Asylum

          Nice! Added. Thanks for the clarification.

  • Stegosuarus

    Should we have a list of dies ease names????
    Like
    Gods rage
    Fattybutt, lol I don’t know y it’s funny
    Ect

    This country info is taking along time there’s like 100 country’s

    • Markham Asylum

      Hey Stegosuarus, feel free to drop any other funny disease names in the comments, but I’d prefer to leave that mostly up to the players’ imaginations, so I won’t be including a section for them in the guide. Thanks for the idea, though.

      • Ultroman

        The simplest disease-name I’ve found, was the funniest throughout the game.
        It was simply: Shit
        “Shit is global”, need I say more? ^^

        Also these are funny:
        Shitstorm, Shitstain, Shitbreak, Bieber, Acne, Assfungus, Chocolate, Snooki, Pigsweat, Hentai, Smoking, THC, Guano, Golf, Madness, Vampirism, Douchedom

  • What the french toast

    Contaminated Pack achievement…

    The key is to have a country that is non-infected with all the countries around it infected. Also you should have extreme hemo extreme zoonosis and profuse bleeding combo. The best way to do this is to get China nuked (with the guide above…) with the transmissions/symptoms above. Then you should get the achievement

    • Markham Asylum

      Bullseye.

      • watergirl

        I got it just now! But I started in the USA, used blood 1&2, insect 1&2, with extreme hematophagy, drug resistance 1&2 heart and cold 1&2. I evolved anemia and hemophilia and then devolved anemia.

        • watergirl

          Also, i disagree that the “key” is having an infected country with all the surrounding countries being infected. When I got this achievement I sent contaminated blood from the US to The Caribbean.

          • Night1505

            I just got this achievement without having to have heat and cold resistance, and only having blood 1&2, insect 1&2, extreme hematophagy, and drug resistance 1. I also let the couphing symptom mutate without devolving it, but it didn’t have any noticeable impact.

            I started in the USA, and evolved in the same order as in watergirl’s post, and only had 219 people (all in USA) infected when suddenly the message “Contaminated blood shipped to Sweden” shows up. I think it might be just kinda random, and that the blood, insect, and hematophagy are probably the key, not where you start it (although, a rich country might be your best bet, since I doubt poor contries ship blood around very often).

            My disease was stuck in the high 40′s for infection for quite a while, since I evolved blood, insect, and hematophagy before drug resistance. Even then, it jumped from 9 to 45 after the “Festival of Love in the USA”. Once I finally evolved drug resistance 1, my infection started to climb pretty quickly. Then, I got the message that contaminated blood had shipped out of the country.

            Hope this helps :)

  • http://stu-in-flag.net stu-in-flag

    Finally, Russia Nuke Achievement!!!

    Forget everything I said up above. I remembered reading that the developer had said that it is theoretically possible to get the achievements in any mode and at any level. So, it’s all a probablistic problem. There is a chance that is not random, but based on a probability. That makes it feel random, when it is not.

    I started on Casual level with Bacteria introduced into Indonesia. I added Drug Resistance 1,2 first. I added Water 1 when I got the Ship Sterilization warning. I added Cold 1. I quickly got the US infected. As soon as I could I moved through Coughing, Pneumonia and Pulmonary Edema.

    The president became ill very fast after this. I was out of points so I added Insomnia, Paranoia, Seizures and Insanity as fast as I could.

    I added Cold 2, Livestock 1, Insect 1 and Air 1 to help with getting the entire globe infected. When Spalin became president, I waited only adding Genetic Hardening and Reshuffling as I had points. When Spalin threatened the Russians, I added Inflammation and Paralysis.

    Spalin nuked the Russians pretty fast after that.

    I finished the game by adding tons of lethal stuff and won. The Achievement was rewarded even though i was on Casual Mode. So, I bet it is theoretically or statistically possible to get the nuke on any level with any pathogen, but it might be darn near impossible.

    • What the french toast

      The chance that Palin will treaten Russia or China is about 40%. The way to improve this chance is to devolve insanity after Palin gets elected!!

      • UGA1998

        Thanks for the assist with the Nukes. I got Russia & China based the information you two provided. Peer Pressure is when the public suspects a disease in your country of origin. It escalates to a riot and finally discovery even though your severity is under 2, which would normally be undetectable.

        My strategies involve buying cheap, but high severity symptoms in the beginning of the game to get more DNA points per infected country and then devolving them under severity 2 before my host country is completely infected. This is essentially how you get the peer pressure achievement. It is actually forced me to change my highest scoring way of playing because This happens to me every time I played this way.

        So to get it: Buy insomnia, Cysts, Paranoia. Get some transmission (air 1,2). Infect 5 or 6 countries and then devolve all three symptoms. Get Coughing and no other symptoms. Keep getting abilites and transmission. Eventually, you will see the events unfold as described above.

  • What the french toast

    Also, anybody have the peer pressure achievement?? I cant figure it out

    • Anonymous

      I got the peer pressure achievement while trying for the nuke. Did not seem all that hard. I think the plague needs to be unnoticed.

      • UGA1998

        What the French. I posted peer pressure in the post above accidentally. Thanks again for your and stu-n-flag’s nuclear assist.

    • Sere

      Make a disease, dont have any symptoms, and wait for this message:
      -Rumours of mysterious disease in XXXXX(your starting country)

      After this, you will get a series of messages: first that the citizens in country XXXXX are trying to get the government to believe that the plague is real, despite the fact it has no symptoms. Then you’ll get a message saying that Riots have taken place, forcing the government of XXXXX to begin searching for the plague. Finally, you’ll get a message saying that XXXXX has found your plague.

      At least thats how I think it goes; the time I got the achievement I was doing a nano-virus brutal run, so I didn’t really concentrate on the messages that popped up.

  • Stegosuarus

    Riots and earth quacks happen after a bit in the game so off you be patient and make your diesease unnoticeable it would happen but there is a low chance of a riot

    • Oli the plague

      Btw that stegosaurus name stuff was me

    • Markham Asylum

      Interesting, thanks.

  • oilman

    this is what i found out from Neurax worm with their base prices
    TRANSMISSION:
    Concertina Locomotion(2dna)
    =>Undulatory Locomotion(up)(2dna)
    ==>air 1(up)(6dna)
    ===>air 2(up)(11dna)
    ====>air 3(up)(18dna)
    ==>water 1(up right)(7dna)
    ===>water 2(up right)(13dna)
    ====>water 3(up right)(must have eggs 2)(9dna)

    Eggs 1(2dna)
    =>eggs 2(up)(2dna)
    =>bird 1(down left)(6dna)
    ==>bird 2(down left)(14dna)
    =>insect 1(down)(5dna)
    ==>insect 2(down)(16dna)
    =>rodent 1(down right)(6dna)
    ==>rodent 2(down right)(10dna)

    Genetic Swap(2dna)
    =>mutative regenration 1(down)(3dna)
    ==>mutative regenration 2(down right)(5dna)
    =>corpse feeder 1(up right)(1dna)
    ==>corpse feeder 2(up)(3dna)

    SYMPTOMS:
    Neural Breach(1dna)
    =>Cerebral Tendrils(up)(2dna)
    ==>Confusion(up right)(4dna)
    ===>Memory Loss(up right)(6dna)
    ====>Aneurysm(up right)(2dna)
    =====>Aphasia(up right)(6dna)
    ======>Apraxia(down right)(6dna)
    ======>Coma(up right)(8dna)
    =======>Brain Haemorrhage(up)(28dna)
    ==>Frontal Mesh(up)(1dna)
    ===>Perceptive Jolt(up right)(6dna)
    ====>Occipital Mesh(up right)(1dna)
    =====>Akinetopsia(up right)(3dna)
    ======>Hallucination(up)(6dna)
    =======>Blindness(up right)(8dna)
    =======>Schizophrenia(up left)(10dna)
    ====>Perceptive Shift(up)(8dna)
    =====>Cognitive Scrambling(up)(8dna)
    ======>Acute Encephalitis(up left)(26dna)
    ===>Immaturity(up left)(7dna)
    ====>Mania(up)(7dna)
    =====>Aggression(up)(9dna)
    =====>Obsession(up left)(1dna)
    ======>Insanity(up)(10dna)
    ==>Adrenergic Constriction(up left)(1dna)
    ===>Anxiolytic Infusion(up left)(2dna)
    ====>Psychosis(up left)(3dna)
    =====>Deapair(down left)(4dna)
    ======>Suicide(down)(27dna)
    =====>Adortion(up)(11dna)
    ======>Devotion(up)(5dna)
    =======>Opsession(up right)(1dna)
    =======>Transcendence(up left)(19dna)(end the game with enslaving humanity)

    ABILITIES:
    Trojan Planes 1(3dna)
    =>Trojan Planes 2(down right)(5dna)
    ==>Trojan Planes 3(down right)(6dna)
    ==>Trojan roamers 1(down)(3dna)
    ===>Trojan roamers 2(down)(4dna)
    ==>Trojan destroyers 1(up right)(3dna)
    ===>Trojan destroyers 2(up right)(6dna)

    and sorry for the re-post last post didn’t have all the symptoms

  • NJatTheDisco

    Contaminated pack?! Anyone? The strategy someone posted before is very vague. Thanks :-)

  • Big Irms

    Beat Neurax worm on brutal…Some Neurax symptoms have a negative severity effect. This strategy will let you infect the world everyone without the disease being noticed, then let you strike.

    Infect the World—
    Start with China, then wait until you have at least 17 points,

    Neural Breach (-1)
    Cerebral Tendrils (-3)
    Adrenergic Constriction (-3) – decreases severity
    Anxiolytic Infusion (-5)- decreases severity
    Eggs 1 (-2)
    Concertina Locomotion (-3)

    Next set to evolve – 21 points
    Anxiolytic Infusion (-5) – decreases severity
    Psychosis (-7) – decreases severity, severity should not be negative
    Eggs 2 (-4)
    Undulatory Locomotion (-5)

    Next set to evolve – 26 points
    Frontal Mesh (-6)
    Perceptive Jolt (-12)
    Occipital Mesh (-8) – decreases severity

    Now your severity should be lower than at the start of the game. Evolve the following as you have points to spend:

    Drug Resistance 1, 2
    Heat 1, Cold 1
    Genetic Hardening 1, 2

    Use trojan planes to spread in infection and wait until everyone’s infected.

    Then evolve the following all at once:
    Despair, Suicide
    Immaturity, Mania, Aggression, Acute Encephalitis

    Now the disease will be noticed and cure development will happen very quickly, you should have enough points left to reshuffle genetics three times until enough people are dead to make the cure impossible to find.

    • Markham Asylum

      Good strategy! Thanks.

    • jjg4w

      That worked like a charm. Thank you!

      • Nintura

        nice, but why kill them? If the world is infected, and you have 0% cure, why not rush the devotion one and have them worship you? it hits all at once, and 2-3 days after you evolve it, they auto worhip and you win.

        • Nintura

          K, cancel that. Seems enslaving it only good for the ahievement. You lose score because you dont kill people.

  • Sophia

    A small tip about the iCure Device event. The even is not immediate, it takes time to go into effect. If your disease causes sweating, the iCure device will break due to the screens getting wet, so it won’t quicken the research.

    • Markham Asylum

      Thanks, Sophia. Added.

  • Andrew Staley

    Prion Abilities
    Neural Atrophy 1 – Neural breakdown causes breakdown in concentration – complex tasks become harder. – Cure Defense
    Neural Atrophy 2 – Axonal swelling causes disorientation and intense confusion – complex tasks become harder. – Cure Defense
    Neural Atrophy 3 – Cell death results in severe short term memory loss – making complex tasks significantly harder. – Cure Defense

    • Markham Asylum

      Added. Thanks, Andrew.

  • Oli the plague

    Special plague info
    Hidden plague: government will not do anything to stop your diesease from spreading
    No cure: cure research stops at 99%
    Infinite money: start with 2000 DNA , still able to lose it all
    Neurax worm: what first starts off as a parasite that has first encounters humanity for the first time, use and mutate it to control humans to infect enslave ect. It quickly infects and can easily get lots of severity

    • Markham Asylum

      Nice, thanks. Updated.

  • Stu-in-Flag

    Looks like for the Nuke Achievements you need to specifically add Bird 1,2 for China and Cold 1,2 for Russia. It may be important to do this after Spalin is elected and before the threat.

    • Markham Asylum

      Cool, thanks Stu.

  • Oli the plague

    If anyone has an iPod game called pocket planes I made a flight crew dedicated to this website ,the crews name is deltaattack

    • Markham Asylum

      Thanks, Oli! You may be one of our biggest fans so far.

      • oli the plague

        i just like helping people :D

  • Anonymous

    I am having trouble with fungus. Iam using the above strategy to not evolve any symptons until i have full infection, however, I can’t infect new countries without spending so many DNA on the ability I have none left to hold off the cure. What am I missing in my strategy?

    • bis irms

      Patience is the key. You really shouldn’t use your DNA points for spore burst, if necessary, for the last country to two, but let the fungus infectivity do its thing.

    • LetMyPeopleGo

      I just evolved spore spread a few times, put a couple into insect and into air, then bided my time keeping symptoms except cough deevolved. And then once I hit about 90% infection (be patient) and then I took cough up to total organ failure.

      BTW. I started in Greenland, only other abilities were hot climate 1, both drug resist, and then hardening as necessary. maybe 1 shuffle

      • mariola

        I just found out a nice tip. At first, when youre spreading at your initial country with coughing and sneezing, is when you get more points for the “orange bubble”, but as soon as this country reaches 90% of infected population, you have to devolver sneezing in order not to be caught. So the trick here is to expand to more countries at the beginning.

        You will notice you have 12 spore releases and 2 spore burst. If you use that DNA fragment that prevents ability costs from rising, you can spend only 8 DNA points in evolving 6 spore releases and 1 spore burst. THis means you would have infected like 12 countries, hopefully some of them being greenland, iceland, new zealand, madagascar, or any other bitches.

        As soon as you have infected these, evolve coughing and sneezing. DNA points would increase sharply, at a much better rate than if youre infecting onle 1 or 2 countries, and the infection would spread smoothly in several parts of the world. The rest is the same, as soon as your original country reaches 90% of pop, devolve sneezing and be patient.

        When you only have 6 or 7 countries left, luckily you wouldnt have been caught, but if so, cure funds should be low. THen is the moment to spend another 8 DNA points in spore release and spore bursts and, voilà, all the countries are infected now. Wait until no healthy people in the world, and then go for the usual combo (to total organ failure through sneezing way).

        I found it helpful to use the DNA fragment “popping cure bubbles gives DNA points”, since at the end of the game they start researching and you start being mortal. Thats my strategy, and always works in brutal. Lovely.

  • black death

    Has anyone figured out the Contaminated Package achievement? “Let humans spread the disease via blood transfusion”… I’ve infected the whole world with just blood 1&2, done it again with those and with the”bloody” symptoms on the bottom right. Nothing.

    Also, I’m still having trouble infecting the astronauts. Any tips?

    • watergirl

      This one is still posting me off too.

      • watergirl

        Uhhh… *pissing me off

        • yoyoyo

          try using like its max upgrade so like start in africa nd upgraid both blood and bugs then the one that that creates ima bout ta do th@ nd get the swine flue achievement with it

  • tv22

    Love this game! I got it about a month ago and have gone through much of it but just can’t seem to get past Bio Weapon on Brutal. Had struggled with Nano Virus but the other day just started a new game and blew it away. With Bio Weapon I seem to have two persistent problems – one of the northern countries doesn’t infect fast enough or at all, or I get a country where the plague dies out (or worse yet, they bomb the ill and wipe them out!). The underlying problem is that even when I’m close, the cure is at times unstoppable.

    I use the Egypt start, go air 1, water 1, meds, water 2, sometimes livestock, air 2, cold 1 and 2. I hit the lethality resets (the one on the right, not on the bottom which doesn’t appear to work other than to get you closer to annhilation) as needed to keep the cure from developing. Basically what happens is I get close and sometimes close even with the cure around or less than 50%, but I can’t get any more DNA since the last people are getting infected so slowly and the cure just cranks on.

    Any ideas?!?!?

    • Markham Asylum

      Hey tv22, I’m glad you enjoy the game so much. Have you used the strategies in the comments above?

      • tv22

        Hi Markham, should say I love your guide and the comments as well. Yes, I’ve followed a lot of the strategies here, just kept coming close.

        So yesterday, a few hours after posting here I fired up the game again and blew it away on Brutal and now have opened the Neurax Worm. The one change I made was not devolving symptoms, but it helps that it evolved the ones that I wanted (insomnia, anemia, etc.). That helped me get the DNA points I needed to keep infecting and still had enough to up the lethality at the end. I was able to get the cure stopped in the 80% range as my plague (Puppies!) took over (it was nice to not see the message “Puppies will be eradicated!”

        A couple of fun names I’ve used by the way – Beer is always a good one, wife and kids names also can be funny.

        Thanks again, on to Neurax!

        • Markham Asylum

          Nice work on crushing it!

          Thanks, I’m glad you have found all this so useful.

  • jack t

    Hey I tried to get rid of the genes that I put in to the genetic code before the game starts but now it refuses to remove them. Is there a special button I need to click? Please help thanks:-)

    • Markham Asylum

      Hey Jack, I’m not sure what you mean about allocating genes before the game starts. Can you be more specific?

      • Big Irms

        There is a little minus sign on the lower right corner.

  • David R

    Anyone know how you unlock the genes you can select at the start of the game (without paying for them)? I got the first few just by playing a few games but have not had any new ones for a while.

    • David R

      Never mind figured it out.

      • Markham Asylum

        Nice! Care to share, in case others get stuck and look here?

        • mariola

          You only have to beat it in CASUAL… I know we drop casual as soon as we beat once or twice, but if you keep beating it, youll get all the genes eventually. 100% guaranteed :D

  • Malefecent

    I found that my favorite name/plague is…

    Children as a name and parasite as disease. Had to share that one.

    BTW primary symptom? Nasuea

  • Derkurnen

    Hey Markham!

    So glad you put this together. It was very helpful when I began playing.

    I noticed that under Nano-Virus Abilities, the Drug Immunity Ability is missing. In my game, Drug Immunity became available after acquiring Drug Resistance 2 with Code Fragments and Radical Elements already taken. I’m not sure if Code Frag and Rad Elements are required for Drug Immunity to become available. Needless to say, this ability… increases infectivity in wealthy countries.

    Thanks again for this guide!! Awesome!!

    • Markham Asylum

      Hey Derkurnen, thanks for the tip; I’ve added it to the guide.

      I’m really glad you’ve found all this info so useful. I’ve put a lot of work into it, but I think the community of readers has done just as much, if not more.

  • Polar

    Just realised that the Gene Compression and Deactivate Genes were the wrong way round on the guide. Gene Compression only slows lethality growth, whereas Deactivate Genes reduces it.

    • Polar

      EDIT: Actually, I think all of the bioweapon abilities are the wrong way round. Correct me if I’m wrong, but that’s what it looks like.

      • Markham Asylum

        If you or someone else can confirm, I’ll gladly update the guide.

  • Big Irms

    Ok, here it is…Modify Genetic Code Info. (I was able to unlock all the genes in one long gaming session; I unlocked one gene at the end of every game I played by playing Bacteria/Virus on Casual and destroying humanity within 365 days.)

    DNA Genes:
    - ATP Boost = 8pt bonus DNA boost at the beginning
    - Cytochrome Surge = popping orange, DNA bubbles now worth 4 pts
    - Metabolic Jump = popping red, biohazard bubbles now worth 4 pts
    - Catalytic Switch = popping blue, cure bubbles now worth 4 pts
    - Metabolic Hijack = Orange and Red bubbles are auto popped for you
    ***Metabolic Hijack is really useful if you have end up spreading your plague so fast that you can’t pop the bubbles fast enough.

    Travel Genes:
    - Teracyte = + chance of plague spread by land
    - Aerocyte = + chance of plague spread by air
    - Aquacyte = + chance of plague spread by sea
    - Suppression = plague more likely to cross a closed land border
    - Native Biome = + infectivity in your starting county

    Evolution Genes:
    - Ionised Helix = Bonus DNA when devolving = +4
    - Translesion + = Costs to devolve don’t increase
    - Sympto-Stasis = Symptom costs don’t increase but easier to cure
    - Patho-Stasis = Ability costs don’t increase but easier to cure
    - Trans-Stasis = Transmission costs don’t increase but easier to cure
    ***Sympto-Stasis is good if you are the type to buy your abilities and transmission first to let your plague spread and then strike. Whole lot of DNA points left to spend!

    Mutation Genes:
    - Darwinist = + chance of mutation
    - Creationist = – chance of mutation
    - Genetic Mimic = Plague harder to cure
    - Base Oxidisation = plague can mutate transmissions but easier to cure
    - Base Hydrolysis = plague can mutate abilities but easier to cure
    ***Mutation genes need a kick start. They are slow to react unless you buy transmission/symptoms/abilities that also encourage mutation, then it can take off.

    Environmentalist Genes: (last ones to unlock)
    - Xerophile = Gives plague bonus in arid climates
    - Hydrophile = Gives plague bonus in humid climates
    - Rurophile = Gives plague bonus in rural environments
    - Urbophile = Gives plague bonus in urban environments
    - Extremophile = Gives plague a minor bonus in all environments

    • Big Irms

      Sorry, typo…
      - Catalytic Switch = popping blue, cure bubbles worth 2 DNA points

      • Markham Asylum

        Nice work, Big Irms! Your valuable info has been added to the guide, and your name is now orange in the Special Thanks section.

        • Big Irms

          Glad to help!

  • Enjoo

    Any extra brutal tips? I keep not having enough DNA points to upgrade because I am devolving mutations… Then the cure increases exponentially.

  • TofuCurry

    Ok, so in 1.4, now you only need one of each of the following to get the next gene…

    Bird 2, Livestock 2, OR Rodent 2 unlocks: Extreme Zoonosis
    *Rodent 2 also unlocks Bird 2 and vice versa

    Insect 2 OR Blood 2 unlocks: Extreme Hematophagy

    Air 2 OR Water 2 unlocks: Extreme Bioaerosol

    Cold Resistance 2 OR Heat Resistance 2 unlocks: Environmental Hardening
    *Cold Resistance 2 also unlocks Heat Resistance 2 and vice versa

    I think that’s it.

    • TofuCurry

      Ok, I was wrong on all counts, ignore my comment. It APPEARS to unlock them, but the grey that shades over the trait is a different shade than if you don’t have enough to evolve. My mistake; delete the comment if you wish.

  • scarper

    Is nuerax worm available for Android yet, bought full version and beat on brutal yet no nuerax worm, has achievements for it but can’t play it

    • watergirl

      I’ve beaten the game on all levels twice now (on my Droid) and haven’t been able to unlock it either.

      • scarper

        Well im bummed, the worm sounds bad a**

        • watergirl

          I just read the google play thingy and it says the neurax worm will be available at the next update. Along with some zombie something or other. Update needs to be updated right now.

          • scarper

            Sweet, thanks

            • scarper

              So just updated and still no worm

              • watergirl

                It’s good to go now! But you will have to beat the worm on brutal to re-unlock the cheats.

  • lewy

    today 01/11/12 i have just got the infect space and make USA nuke Russia achivements. : )

  • scarper

    Lewy, how did you get USA to nuke Russia? Where did you start? Ive followed the process posted with no luck

    • lewy

      I played with the no cure cheat. started in USA and was trying to do the infct space achievement to be honest and ended up doing both! i had AIR+2 and WATER+2 then extreme bioaerosol. Also Drug resistance 1+2 with HOT+2 and COLD+2 then Environmental Hardening. then ALL none lethal symptoms.A little later got a message saying they were going into space to find a cure, some more time past and got another saying that two men had left earth to find a cure. After that i straight away hit SEIZURES and INSANITY also PARALYSIS. little later got the messages saying i infected space and also that SPALIN had been elected and then that she blamed RUSSIA for infecting the world and nukes them.

      hope this helps. any more questions im happy to help.

    • lewy

      Sorry also i evolved Tumors and Fever to speed up the process. at the same time as insanity and paralysis

      • watergirl

        I’m going to try this today :)

        • scarper

          Thanks, going to try right now

  • watergirl

    Am I the only one who refers to this game as “KILL ALL THE PEOPLE!!!”?

    • scarper

      So ive spent all this time infecting the world and what happens?…………..I get extremely sick, out for a week! Karma?

      • Markham Asylum

        Hilarious!

  • grasscid

    You have a bit of inaccuracies here, but for the most part, it’s all good.

    DISEASE TYPE; You got them mostly right, but you missed the mark with bio-weapon, parasite and nano-virus. The bio-weapon does not have “extremely high lethality”, but It’s lethality does progressively go up the longer you play, even without symptoms. The parasite is, for the most part, wrong. I’m not sure about the “extra points from dna bubbles” part, but I can say for certain that it does get the red infection bubbles. The ACTUAL downside to the parasite is that you do not get points for infecting people. However, you still get points for popping red bubbles, orange bubbles, cure bubbles (Only if you have inserted the gene that allows you to do so) and for killing people. Lastly, you are entirely wrong about the nano-virus. None of those facts are correct. The nano viruses features are simply that the cure starts as soon as you start playing the game. I think everything else is identical to bacteria (except, of course, their respective exclusive abilities), although I can’t say 100%.
    SYMPTOMS: Anemia has no lethality, even though you have it listed as such in its description. Paranoia and insomnia work similarly to genetic hardening, I believe.
    ABILITIES-
    BIO-WEAPON: You got them all mixed up. Gene compression is the only one that slows lethality growth, and does nothing else. DMG greatly lowers your lethality, but does nothing else. NAN, well, I don’t know what it does. The only use it seems to have is to get the annihilate gene :3
    FUNGUS: I think It’s worth mentioning that spore burst and eruption always cause a random country to become infected when you unlock them.
    NANO-VIRUS: You forgot to mention that broadcast interceptor overload slightly reduces amount of time need for a cure after the giant increase runs dry.
    NEURAX WORM: You left off a key feature of trojan destroyers: It causes people in the trojan planes target country to start dying, even without any lethal symptoms all though it takes a certain amount of infected people before it will happen. I tested this by sending all my trojan planes to Greenland, but devolved any and every lethal symptom except trojan destroyers and sure enough not only did people start dying, but It was also the first destroyed country and the only one with ANY deaths. Afterwards, I directed every plane to Australia and once again, they where the second ones to go down. Also on a side note, their are only two trojan destroyer upgrades avaliable whereas your guide says there are three.
    MODIFY GENETIC CODE: Misspelled “whole” in the last line of evolution genes :3
    Everything else seems to be good; Just fix these little things and you’re all set. :)

    • grasscid

      So Nan is supposed to “Reset the lethal potential of weapon.” I however see no difference when I activate it, which is why I said it supposedly does nothing.

      • Markham Asylum

        Thanks for the corrections, grasscid. I made all the changes you suggested except the ones for Bio-Weapon, since you didn’t seem too sure about them and the information that is here was given by another reader. If you can say definitively that you know exactly what all the Bio-Weapon abilities do, I’ll gladly update them as well.

        • grasscid

          It appears you misunderstood what I said about parasite, or I may have written it in a difficult to understand way. :P You have it listed as not giving points for DNA bubbles now. Lemme try to explain this simplistically: You know how when you play, you will randomly get points? Not by popping any bubbles or devolving anything; just random points? You can get those for infecting people, the quicker you infect, the more points you get. Same with killing people. The faster you kill everyone, the more points your disease will produce. While the parasite does get points for killing, the points for infection are absent. You still get points for infecting new countries, and popping DNA bubbles and all that jazz. Hope that clears it up. Also, you’re still kinda incorrect about the fungus abilities. Spore burst increases infectivity (Got that part right) but also infects 1 random country. Spore eruption also increases infectivity, but infects about 5 random counties. Spore hardening increases infectivity as well, and will periodically (Once every minute or so) infect a random country. Lastly, I can certainly confirm the bio weapon abilities. I can take a picture on my ipod of the abilities and their description and provide a link, if you want. I don’t really know how to definitively say it any other way :S Anyways, this is a very good guide. I could provide strategy tips too, if you want. I know how to beat them all on brutal easily, but it requires the genes from the genetic code update. ;)

          • Markham Asylum

            Ok, I think I’ve got them corrected now; please confirm.

            • grasscid

              Just change the world “score” to “DNA points” on parasite and you’re all good. As for everything else, “confirmed” :)

    • wow

      Grasscid, very helpful post. Very professionally written :D

  • Bbob1000

    Countries with the highest healthcare is a good place to start build up transmissions symptoms and abilitys focused on the rest of the world then unleash everything with the drug resistance ability

  • PAX-12

    i like the game. what is the most effective disease type to beat the game for short time? thanks for the reply:))

    • scarper

      Bacteria, do it in 365 days or less for an achievement

      • Big Irms

        Bacteria or virus…it’s also good practice if on brutal… Best I’ve done is virus-brutal in under 300 days.

  • bldizon_93

    What’s the best country to start out on for all? I haven’t beat any of normal and tried really only USA, Russia, and china. Also, tried only having coughing at beginning but I usually buy all transmission.

    • bldizon_93

      Also you can view a country’s details before you start your destruction of earth by holding your finger there for a few seconds. Lastly, how do u check countries severity? That way I know when to stop for a bit

      • Big Irms

        My go-to country is China. I always use it on all difficulty levels to find out how a plague works or how the updates are affecting the play.

  • bldizon_93

    And forgot again it was supposed to say bldixon_93, and sorry for three in a row

  • http://thewebrecluse.com thewebrecluse

    What does it mean when an entire country just goes pale red all at once as opposed to the little red dots?

    • bldixon_93

      I think it means the country is or nearly is overtaken by the virus or other pathogen

      • oli the plague

        im sure if turns into a shade of red it means its having trouble spreading oh long time no see

  • froggyyaya

    How do you get the neurax worm. I bought the game. Beat the whole thing on normal and am almost done with brutal but still haven’t gotten the worm. Help

    • bldixon_93

      I believe u hav to beat all modes on brutal then u unlock all the cheats including the worm

      • Burns

        This is not the case for android as I have but 3 achievements left to receive

        • hawk

          To get the worm, just beat everything on brutal.

  • Joyceypoo

    I’ve tried and tried to beat bacteria but for some odd reason I can’t! Could you please help me!

  • CRACKER

    Have not noticed anyone point out that cold resist is cheaper than hot so better to start in a hot country. I prefer Egypt. Great help, thanks all for the great info!

  • I NUKED RUSSIA

    hi guys if what the site says is true than i am the first one who managed to nuke russia (forgive my bad english i’m writing this quickly)

    here is how i nuked it:
    choosed cheat immune plague disease type

    started on russia with BRUTAL difficlulty( i guess such a brutal attack needed a brutal game)

    infect all the planet , with all non-letal symtoms , than with ONE letal symptom start killing ( i used necrosis) , soon you’ll get the message “usa president taken ill”

    than you must stop killing and upgrade only the insanity syimptom (and non letal ones)

    wait for spalin to be elected, than REMOVE insanity, i don’t know why , thats just the way it happened, whait for the message ” spalin thinks russia deliberately released PAX – 12 etc etc swears revenge ” buy AGAIN insanity AND paralisis(
    paralisis and insanity will prevent american generals to stop spalin’s plan to nuke russia) within kinda a week you will recieve the message “usa nuked russia”

    i didn’t try this on china but i belive is the exact same thing ecept you should start from there

    hope it helped :D

    …wow was i really the first who did it ? :P

    • David

      I’ve nuked Russia as well, but mine didn’t involve the crazy evolving/devolving symptoms strategy you employed. I also didn’t start my disease in Russia, so it doesn’t seem to matter where you start it. You do need those Paranoia and Insanity symptoms, as far as I can tell from the similarities between our games, and 100% world infection is most likely a must. (It also could have to do with if Russia or China directly infected USA, think about that)

  • Kyle

    Great strategies but I have one question… How do I remove a genetic code before the game even starts? I have one chosen and wish to not have “any” chosen in that category. I have emailed the maker and have been waiting for a couple weeks on a reply…

    • Big Irms

      There is a neg sign….see post above.

  • Ninjawild

    Okay, so I was just messing around with the Parasite disease. I started putting points into Symbiosis 1, 2, and 3. Shortly after just getting the third ability, a message popped up, I’m sure a lot of ppl have seen but have over looked. The message was something along the lines of “Scientists believe an asteroid will destroy humanity in 4024″. And I’m thinking to myself, has anyone tried lasting out and seeing what happens at that point in time in the game? I figure with all three Symbiosis, I can in fact what it out until that time. So I’m in it for the long run. barely at 2060 right now. I’ve only put points into Water 1 due to ships using new sterilization. I also altered the genes to have Translesion so when my symptoms mutate I can devolve and still earn points.

    so my question is: will the game make it to the year 4024? and if it will, will it out beat my plague? How long will it take to get to year 4024? How upset will i be if nothing happens?….

    • Ninjawild

      I figure with all three Symbiosis, I can in fact wait* it out until that time.

      • Ninjawild

        If I’ve done the math correctly, and leave the game running full-time, it will take me roughly 6 days to reach 4024.. at about 5 mins a year, from the year 2070 to 4024, that’s 1954 years to go x5 (mins per year) = 9770 minutes. 60 mins in one hour, so 9770 / 60 = 162.83 hours. 24 hours in one day, so 162.83 / 24 = 6.78472 days.

        • Markham Asylum

          Very interesting find, Ninjawild! Be sure to let us know what happens!

          • Ninjawild

            of course.. i hope something happens at least.. although, it will take a long time.. one thing I’ve noticed is after either a long period of time or devolving symptoms enough times, they don’t mutate any more.. its been about 60+ years since my last devolve..

            • watergirl

              So cool! Can’t wait to find out what happens!

              • Ninjawild

                so im quite disappointed.. i dont think the game was ever meant to make it to the year 4024..

                i finally made it to the year 4024 thinking that the world might end by asteroids as predicted by scientists.. i watched the entire year.. nothing happens.. so anxious i was to see everyone die i filled the symptoms to max lethality on 1/1/4025.. i killed everyone off within 3 months.. and then i get a victory.. only thing is is when i clicked on “Disease Graph” the game freezes up and i have to kill the app (via app killer).. i go back into the game and there isn’t a game to load, so i try the high scores to see what i came out with.. nothing.. my disease wasn’t even listed.. I’m so disappointed.. but it was a far fetched theory..

                so what i learned..
                dont go past the year 4024..
                symptoms almost never mutate after 500 years from starting..
                yellow balloons are just as scarce..
                leap year is still accounted for.. lol..

                oh and I’ve come up with something you haven’t added yet to your Strategy Guide that I plan on adding within the week.. I’m sure it will be useful..

                • Markham Asylum

                  That majorly sucks. You should contact James; he actively monitors player feedback and takes it seriously. I bet he would put an asteroid event in there if you mentioned this scenario.

  • Hexapheonix

    Hey, does anyone know a way to beat Fungus on Brutal? Canada/Greenland/Iceland is annoying me so much every time I infect them and then “An execution squad in Canada eliminates the infected” and Canada ends up healthy again. .-.

    Any strategies/tips?

    • grasscid

      Start in a hot country. Work your way up to extreme bioaeresol from from water 1,2 and air 1,2. Don’t evlove any symptons and if something mutates, devolve it. Get drug resistance one (Drug resistance 2 is only necessary on brutal) and cold 1&2. Then just stockpile points and by the time everyone is infected, you should have anywhere between 50-120 points. Get coughing, sneezing, immune suppresion and total organ failure. If you have any extra points, get anemia, abscesses internal hemmoraging, hemmoragic shock, and necrosis. Once you get more points as people start dying, get coma and paralysis. If the cure is going up too fast, get genetic hardening and genetic reshuffle from the drug resistance tree in abilities. Before you know it, you’ve beaten fungus.

  • grasscid

    Hey Markham, If I’m replying to your reply on my original comment, would you prefer that I reply directly to it, or at the bottom of the page? Because I did reply to your reply using the reply button on your reply (Yo dawg) and you seem to have missed it .-.

    • Markham Asylum

      Just because I haven’t replied yet doesn’t mean I didn’t see it.

    • grasscid

      Alright, just making sure. .-.

    • grasscid

      Happy thanksgiving, by the way :)

      • Markham Asylum

        You too.

        • grasscid

          All I want for Christmas is mutation 1.5: zombies lol

          • Markham Asylum

            Fah sheezy.

  • Bear god

    Any tips on beating virus on brutal????!!!!

    • grasscid

      Start in a poor hot country. Go for extreme bioaeresol from air and water transmission. Then go for skin lesions from rash and sweating. Finally, get drug resistance 1, then cold resistance 1&2, and drug resistance 2 and the 3 viral instability upgrades. Let the symptoms mutate freely, but devolve anything overly lethal until at least Greenland is infected. After you have it infected, get necrosis, and once everyone in the world is infected, get total organ failure or hemorrhagic shock. If at any point in the play through the cure goes up too fast, just get genetic reshuffle. That should get you through it quickly and give you a good score as well.

      • Bear god

        Dude that worked beautifully thanks so much! Also do you by chance know how to beat fungus? Thanks for the help!

        • grasscid

          Yeah. Fungus strategy is similar but you gotta work with the symptoms differently. start in hot country, get extreme bioaeresol. Don’t get any symptoms and if anything mutates, devolve it. Get drug 1, cold 1&2, and then drug 2. However, I recommend bypassing drug 2 if you have >80% of the world infected with less than 50 points stockpiled. After that, don’t buy anything else and let your points pile up. I strongly reccomend the translesion perk for this, which prevents devolve costs from going up on brutal. After Everyone is infected, get coughing, sneezing, immune suppresion, and total organ failure. If you have enough points left, get fever, skin lesions, necrosis, hemmohragic shock. IF scientists have increased understanding of fever, go instead from anemia, hemeophilia, hemmohragic-whatever-it-is, hemmohragic shock and necrosis. If cure goes up to fast then once again, get genetic reshuffle.

          An alternative method is much faster, but requires the patho-stasis gene (ability costs don’t increase.) The metabolic jump gene (bonus points from red bubbles) would also be strongly recommended, but it’s currently broken on the iOS version of the app. What you do is start in GREENLAND, go to the abilities page, and get spore burst. Go back to the world map and pop the bubble. With the points from that, get more spore bursts (though never more than 3 at a time. This is so you have time to pop every bubble that shows up.) until you can get spore eruption, and eventually spore hardening. Then, follow the same pattern as the first strategy with one minor difference- get heat resistance 1 ONLY (not 2) rather than cold 1&2. Follow everything else exactly the same and before you know it, you won :)

  • Katey Carnahan

    Want once my nabi 2. And cannot have!! Please fix.

    • Bear god

      Way the heck r u talking about?

  • Bear god

    Wat*

  • Maki

    I noticed that when the cure reaches 100% and you killed everyone before they start handing out the vaccine you would still see the word “Defeat” and lose when you eradicated the last human while the cure is developed. T T was about to win in brutal..

  • Bbob1000

    The U.S.A is without a doubt the best starting country.As long as you leave the rodent, drug resistance and hypersensitivity alone for now and make sure your plague is not lethal you can evolve ALL other transmissions, as well as a few key symptoms, heat and cold resistance, and build up enough points to make it deadly when the time
    is right, the only thing that can upset this plan is a badly timed ‘festival of love’ which will sometimes get you noticed.When you are ready, one drug resistance upgrade is enough to see infection rates skyrocket and before airports can be closed it will have spread to other country’s where your patience is rewarded. Not quick but almost always lethal, has worked for me many many times.

  • Molk

    Insert Gene??
    I’m playing on android. I found that after i win a game, it says that y “Unlocked” a new gene mutation, supposedly, to insert it on my plage in the next game.
    The screen indeed shows the gene “unlocked” but once i click on it to “Insert gene” nothing appears to happen.. a screen pops up telling me “Want to modify your genetic code? Unlock the full game to get the true plague inc. experience” and the options: [Later] and [Unlock Now].

    So, Does it means that no matter what you do or how many DNA genes you unlock wining games, you cannot use them until you pay to actually unlock and insert them??

    • Anonymous

      that is correct good sir. had to pay for it with my android. totally worth a buck though

      • yoyoyo

        apple doesnt do th@ tho ha :)

    • Jack Bua

      That is correct. Right now I think it costs $1.06 to unlock the game. From that point on, you can just play the game on harder difficulties to unlock the expansions

  • greg

    im not sure which disease type, but if its mutates, it wont increase severity(or lethality) level. only when you directly buy symptom. which one is it?

    • grasscid

      None of them. It was likely a rare bug.

  • Nintura

    trying to see how high of a score I can get. My best record was killing with a virus at 408 days and only 19% cure researched, which netted me 92k score. Anyone have any suggestions on how to get the 5 star rating? I take the genetics to make my disease harder to cure, transmissions don’t increase, then I research a ton of transmissions for the mutations, and let it mutate all those freebies for me while researching the resistances. But so far, I’m unable to break 100k.

    • TO_Asylum

      Nintura – at what difficulty and plague type was your 92k? UGA1998 posted some score data which suggests that the main driver behind score is cure rate: lower the cure, higher the score. That data set suggests you need <10% cure to break 100k. (search on my name to find the post above). However, it may depend on difficulty level and plague type as well. If you (and anyone else!) post your data, I can see about finding out what the full formula is. Ideally include:

      outputs
      -score &star rating

      main inputs
      -difficulty level
      -plague type
      -days
      -cure

      secondary inputs
      -start country
      -genetic code markers (anyone know how much these matter?)

      • Nintura

        Sure, not a problem. Yes, % cure rate is 99% of the score it seems. Getting less than 10% doesn’t even seem possible at Brutal difficulty… I haven’t even been able to get below 20% since.

        Score: 93130, next one below that was 72010
        Star Rating: 4
        Difficulty: Brutal
        Plague Type: Virus
        Days: I believe around 410
        Cure: 19%
        Start country: Either Egypt, Saudi, or India. All 3 work.
        Genetic markers: None of them add to your score. Cheats take away 90%. But for the record I use:
        Metabolic Jump: Extra dna from red. Trying to race the cure.
        Native Biome: Inc. infectivity in starting country. You can start air or sea and that might help more.
        Trans-statis: I want to be able to get as many mutation causing transmissions as fast as I can.
        Genetic Mimic: Harder to cure you. Duh.
        Extremophile: Small bonus in all environments.

        I chose virus because you can get a ton of free dna in all the mutations. I can generally have 4 transmissions before hitting 1k infected. If I’m in India, insect first, water, bird, then air or rodent if I hit China or the US. Then I upgrade the mutation from the virus tree to at least lv 2, by then I got some rich countries, so I get genetic 1 and 2 if possible. Then go back to getting transmissions for as many mutations as I can.

        The trick that seemed to be luck was getting a lethal mutation that allowed you to kill while your infecting, but not enough to kill everyone so that the cure slowed down while youre still infecting.

        • Nintura

          Also, the trick is to get greenland someone early if you can, then you’ll have an easier time. I get cold lv 1 and 2 when I can, along with water 2. But only once you infect europe and norway. Which is rich, and it seems the only boat that goes to greenland.

          • TO_Asylum

            Thanks a lot. Posted some stuff on scoring below. Getting a high score seems easier on bio-weapon, since the kill rate is so high, provided of course you can stay on top of the automatic jumps in lethality. A certain number of deaths seem to trigger the cure research starting, which in turn drives score down – so if you get more than the 3 lethality bumps that you can control with the nucleic ability, mighty as well start over.

            On virus, I can’t seem to rack up enough DNA points (before total infection) to get a kill rate fast enough to keep the cure down. Once I start with the high-speed lethality, the cure goes up about 30% in a month, and I can’t seem to knock off big enough population numbers fast enough to get more points before it’s too late.

            • Nintura

              It would seem the trick is to allow the virus to kill off while youre infecting at the same time. It will slow the cure down, but it does require a lot of luck to get the right mutations in order.

    • Mike

      I’ve cracked 600k on parasite, 1.4m on worm, and 12.6m on nano virus

      • Mike

        The formula depends on the following factors in order of importance.
        1. Difficulty level
        2. Cure rate
        3. Complexity of disease.
        4. Leftover DNA

        • Nintura

          would you mind going into detail on how you did this?

      • Mike

        Parasite and worm are only diseases where u can bring severity to zero. This will allow u infect the entire world without getting noticed. Then make sure you have enough DNA to buy all symptoms, drugs, genes hards and reshuffles. You”ll score big but it’s a patience game 10 years+. Play on brutal.

        There is a DNA loophole on nano virus. It allows you to get unlimited DNA. Just evolve and devolve coma. Buy everything and kill the world. Play on standard.

        • Nintura

          How do you bring severity to 0 on the worm…. even the transmissions give severity.

          • Nintura

            I wasn’t able to figure out the coma dna loophole so they might have fixed it. I’ve evolved and devolved it, while getting 2 back for devolving it, it still raised in price everytime i relearned it.

            • Mike

              U need to use the sympto-stasis gene, ensuring costs don’t increase. On standard difficulty nano-virus, you actually receive 3 DNA for evolving and 2 for devolving. So u get 5 DNA for every time u evolve/devolve coma. U just keep doing it repeatedly until you have enough DNA to buy everything. 900 DNA should do it.

  • B0N3s

    what about the non goverment events like festival of love, Hay-Herbert treaty, tsunamis, earthquakes and such. would you be able to put anything up about those kind of events?

  • B0N3s

    does anyone know if buying the Neurax Worm on andoid unlocks the full game?

    • http://www.ndemiccreations.com james vaughan

      Yes it does!

  • Scott

    No, it does not.

  • Masterhp

    The Virus is the hardest one you should pay attention on. Virus mutates rapidly and will increase the chance of the disease to be noticed. Even if you devolve the mutated symptoms it cost 3 poitns on the first time, 4 on the second one and on. What you have to do is start the game on Brutal, it is easier than normal. Thedisease spreads slowly and will get DNA points faster.

    • Nintura

      no, on brutal it starts at 6 then 4, then gets cheaper.

  • Nintura

    Anyone notice this game being buggy from time to time? I started off in the US as it’s my new favorite starting area, but a few minutes later, i get a message saying my disease has been discovered in Greenland….with 0 infected in the country and only 15 in the US…

    • Nintura

      And right after that, with still 0 infected in Greenland, it started on the cure. At lv 2.

      • Nintura

        Also can we get a full list of the neurax worm traits and what they do? im trying to find the ones that reduce severity.

        • Mike

          See big irms post on sept 15. But remember to score big u need to evolve all symptoms and meds before u lethalize. Need roughly 400 DNA to do that. Will require you sending planes for many years to get to that number. But your patience will be rewarded with Big score.

  • TO_Asylum

    Great site!
    To fill out your last topic, here are some thoughts on scoring (part 1):

    Getting a high score is a separate objective from winning the game – you can win, but getting a high score requires additional work. Some basic regression shows that score depends almost entirely on two factors: cure % at the end and difficulty level. These two factors correlate most strongly, with high statistical significance. In the data I collected (see below) other factors such as days and virus type do not correlate, although I’ve only looked 2 plague types in detail (bio-weapon and virus). The data from UGA1998 support the dominant relationship with cure; however, that data doesn’t include difficulty level. UGA’s data also shows some correlation with days (wasn’t the case in my data), and a weak correlation with infectivity/severity/lethality (not statistically significant).

    Here is the supporting data. Difficulty is Casual=1, Normal=2, Brutal=3. Plague Types are Virus=2, Bio-Weapon=7.

    (Difficulty, Plg type, Days, Cure%, Score, Star)
    (2, 2, 940, 57%, 6050, 3)
    (3, 2, 1138, 80%, 6660, 3)
    (1, 7, 641, 20%, 7850, 3)
    (3, 2, 1198, 49%, 13010, 3)
    (1, 7, 428, 10%, 14590, 3)
    (3, 7, 883, 57%, 16130, 3)
    (2, 7, 797, 24%, 18080, 3)
    (2, 7, 573, 21%, 20610, 3)
    (3, 7, 587, 37%, 28190, 3)
    (3, 7, 641, 25%, 32810, 4)
    (3, 7, 632, 10%, 79670, 4)
    (3, 7, 526, 8%, 81280, 4)
    (3, 7, 637, 8%, 90510, 4)
    (3, 7, 676, 8%, 92650, 4)
    (3, 7, 573, 7%, 125530, 5)

    As you can see in both data sets, you have to get under 10% to get close to or above 100k. As far as stars go, they seem to line up pretty clearly with score: you’re stuck at 3* until you break 30k, and no 5* until after 100k.

    In terms of strategy, I followed a mix of felix and UGA’s. The general notion was:
    -transmit under the radar (devolving all but cough) using air1,2 and water 1,2, sometimes throwing in something else (e.g., bioaerosol, or cold 1,2 if starting in a hot climate, or needles when Africa is slow)
    -if playing on bio-weapon, use all the abilities on the right (gene compression, etc) to unlock annihilate
    -kill as fast as possible when the whole world is infected (e.g., annihilate on bio-weapon, or rushing to total organ failure on others)

    If anyone else has any data on scoring, do share…

    • Mike

      Your conclusions mostly correct. See my post above for scoring factors.

      To crack a score in hundreds of thousands and even millions, First u need to play on brutal, Second u need a cure rate of 4% or less. days doesn’t matter. However complexity of disease is huge. First it lets you get a low cure rate, second it increases your score by rewarding you for evolving your disease.

      To accomplish this, u need to infect the entire world, and then evolve every symptom and all drugs, gene hards and reshuffles. you’ll score even bigger by evolving every transmission and ability, but you likely won’t have enough DNA for that. The more complex ( more evolved traits) your disease, the higher your score and the lower your cure rate.

      The last factor, will take your score from hundreds of thousands to millions is leftover DNA. You won’t have any in parasite. But you will in worm and nano virus. Worm because you can keep sending Trojan planes indefinitely. And nano virus because of DNA loophole.

      • Markham Asylum

        I added your tips to the Scoring section as well. Thanks, Mike.

    • Markham Asylum

      Posted. Thanks, TO_Asylum.

  • Nintura

    You should also update your bio-weapon abilities. I dont think Gene compression reduces your lethality at all. The bar never moves. Same for Nucleic Acid.

    • Markham Asylum

      I’ll gladly do so if you provide complete descriptions of each one.

    • Rodders

      Gene compression doesn’t reduce lethality, it increases the time for the plague to become lethal. This is key for tackling bioweapon on brutal. I found that you can nearly infect the entire world on brutal if you upgrade gene compression to the max, and use a few carefully timed modified genes to ensure the lethality stays at 0.

      The one ability on bioweapon that I’ve been confused by is the Acid Neutralisation, as I’ve been unable to work out what it does, when I upgrade it nothing seems to happen. It doesn’t reset lethality as the description suggests (people keep dying). The only thing I use it for is to unlock the Armageddon Gene.

      • Rodders

        *Nearly effect the entire world without being noticed

  • Anonymous

    Lol name it butter

  • Rodders

    To get the Nuke achievements:

    Nuking: Evolve a non-lethal plague and wait until it has affected the USA. I then evolved to the Insanity gene (gives it a little lethality). Wait a while, then the president is taken ill. Because you’ve evolved insanity, Palin is elected. Then evolve paralysis, which stops the generals preventing her from nuking russia / china. Boom.
    Myths: it doesn’t matter where you start. I started in South Africa when Palin nuked Russia and in India when she nuked China. You just have to make the president ill.

    • Rodders

      *Patience is the key to making the president ill. Make it a little lethal and wait it out.

  • grasscid

    No Zombies ’till late January :,( At least late January is when my birthday is.

  • Bobbi

    I am awesome at plague inc

  • Bobbi

    I have a question how do you make your disease lethal but unoticed

    • grasscid

      You don’t. It’s impossible.

      • yoyoyo

        no if you have all symptoms to swine flue its lethal (its funny i just did this) but any let me start over aight so 1st get a parasite start in china upgrade rodents twice then birds twice animals twice nd get the middle one they make (btw hope you have fast thumbs to) then buy its special all three nd get all the non lethal symptoms to swine flue save up after to get the lethal ones at the same time this should spread fast as hell nd kill at a good rate if youre afraid youd get noticed or a procaution you can upgrade the powers to make the cure level go down p.s this strategy works with others for the most part exept youll get noticed if you start getting symptoms before it spreads all the way cause you dont have symbiosis nd whil youre waiting for it to spread get as much points as possible if you have to much by heat/cold/ or blood or all to spread faster then buy couphing and the next thing that kills fast nd get organ failure still not happy with kills buy the bottom most right nd keep buying to the right you should have good luck with that i hope ive answered your question nd more nd gave you a nice strategy to beet the levels better

        • grasscid

          Lethality is like severity but it kills people. even if you have no severity but some lethality, there is still a chance your disease will get noticed.

  • Wil

    How much is the minimal purchase to unlock full game??

    • grasscid

      Any purchase will give you the full game.

  • Hecko

    Hey i dont know if you know about this: if you have darwinist gen code (which increase the chance of mutation) and ionized helix (which gives you dna bonus points when devolving) you get up to 4 pts per devolution? so that means if you play as any diase,i think (excep for virus) if you play ‘stealthy’ and you get a sympthom (or anything) that you dont want,just devolve and you get 4 dna free (:

    • Ronan Fitzgerald

      GENIUS!!!

  • Rogue Scientist

    Ok, this has been driving me nuts: what triggers the appearance of the orange DNA bubbles? They’re always a sign my plague has been spreading in that country, but what specifically does it mean?

    • grasscid

      They’re completely random.

  • yoyoyo

    how do i get the achievement for the infected on the moon or whatever cause im super good at the game just got it nd practically beet it but it comes with two different things for astronauts saves space station nd something bout them goin to space but they never do? nd how do you get america to nuke china or russia do you have to use a certain plague or what cause i cant get em to do it

    • grasscid

      Read the previous comments. There’s two (I believe) that tell you in depth how to do it :)

    • Mike

      Plague in Space
      Air 1+2, Water 1+2, Extreme Bio whilst starting in the USA. Devolve symptoms after mission planned pop up, wait for mission launched pop up, add minor lethal, wait for mission failure pop up.

      Nuke
      Start anywhere, infect the world, DO NOT use Bird transmissions or cold. Get drug 1+2, go lethal, wait for POTUS sick pop-up. When it happens, evolve insanity, wait for Spalin voted in as new president pop-up.
      Russia- evolve cold 1+2, Spalin will threaten Russia, add paralysis after threat pop-up. Wait
      China – evolve bird 1+2, Spain will threaten china, add paralysis after threat pop-up. wait.

  • Pope

    Is there a place for high score screen shots?
    My personal best is 460k

    • Mike

      No attachments on this site.
      My personal best in 18.63million

  • malcolm taynuu

    So heres my stradegy for bacteria, fungus, parasite and prion.dont evolve any symtoms until everyone is infected. Devolve any mutated ones.focus on transmissions and get drug resistance and genetic hardening at the middle. Once everyone is infected, get total organ faliure,which starts at cough.also you will need to get genetic reshuffle when the cure is being worked on

  • klackerer

    The neurax worm has a different set of symptoms then normal diseases. The only 2 symptoms it share’s with regular diseases is coma and insanity It also has some different transmissions (It does not have blood and livestock and it has some extra ones. Also the Trojan plane goes anywhere regardless of closed airports, and lack of airports so it is really useful for that one country that won’t let you in. The most fatal of these are : brain hemaphorage, coma, suicide, acute encephalitis, and aneurysm. The next most fatal things are blindness, insanity, and schizophrenia,

    • Ronan Fitzgerald

      I don’t try to kill, its WAAAYYYYY more effective just enslaving everyone. Trojan plane is very helpful for…duh duh duh…GREENLAND!!!!! THE HORROR!

  • Fran

    Hello, for when it will be available in Spanish?
    Thank’s

  • B516

    I didn’t see anything mentioned on what affects the number of DNA points you get outside of bubbles. This varies so greatly over the course of the game that it would be really helpful to know what factors into it, so if I’m getting near the end and desperately need DNA pts, I may be able to get some.

  • http://www.facebook.com/zane.teal Zane Teal

    This game is such bullshit. On bacteria, normal level, I have yet to win a game, despite trying every one of these so-called “strategies” posted by other people. No matter how slowly I build the symptoms (so it can fly under the radar), or how strong I make its defenses, the cure always progresses at a ridiculous rate at a point in the game where it gives me no DNA points. Seriously, I know some people like it when games are difficult, but too much difficulty takes away most of the fun.

    • TMDG

      Play better. It is possible to infect the whole world without getting a single upgrade, by that time you should have over 230 DNA points, then just make it as lethal as possible, it might take several hours to infect everyone this way, but should only take a couple of minutes to kill all humans

    • big irms

      Patience…the key is to not build symptoms at all, just infectivity.

    • scwatergirl

      You’re doing it wrong then.

    • http://www.facebook.com/justin.clum Justin Clum

      Bro, you just suck at this. As bacteria, upgrade transmission and abilities (especially genetic hardening and genetic reshuffle) and devolve all the symptoms as soon as they mutate, and wait for all the countries to be infected. When you get the notification that there are no healthy people left in the world, evolve multiple organ failure and perhaps coma if you have points left over, and people will drop like flies before they can finish the cure

    • Ronan Fitzgerald

      Listen – de-mutate all your mutations UNLESS you’ve been discovered, then leave them. Upgrade all the transmission upgrades once (just buy them) and a couple of the abilities. Start in egypt or south africa, poorer places but have ports and airlines. then, when you discovered pick the middle top symptom, then the left branch, then bottom or right branch, then bottom/right branch. DEATH TO ALL

    • Chuyito

      Lol just got it on my first try.

    • http://www.deltaattack.com/ Markham Asylum

      Hey Zane, I added a Strategy section to the guide that comprises the two most helpful user-generated tactics from the comments. If you’re still interested in this game, I hope they help you out.

  • Laurent-Guillaume Sémat

    If found a good way for Transfusion Blood achievement.

    This is also usefull when an island can’t be infected due to awarness.

    For Transfusion Blood you need to be stuck in poor and hot countries infection. Like Africa or mostly esay new guinea.

    1 – In want Hotter countries at least, so I start form colder like Iceland, it’s gonna be slowwly to infect but I’ll be sure to have an hotter island closed.
    2 – Use blood and insect transmition, cold resistance 1, and then upgrade blood to lvl 3 (with insect), you can have air 1 / water 2 in order to help but take care to not infect all of hotter/poor country. Dont forget Drugs resistance I got lvl 2 but I don’t know if it’s usefull
    3 – Increase your plague Severity & Infectivity, rash, sneezing, coughing it’s a good way to deal because we have started in cold country.
    You need high severity in order to close all land/border quickly
    When awanress is hight look if new guinea has closed everything. Then, it’s time to make your plague very infective.
    Up cold and hotter resistance to 3, air/water to 3
    DO NOT up a bird/rat/livestock to 3 or island will be infected by animals (the way to get in closed colder country if you start from hotter)
    Keep hightest infectivity for your plague, you can start to kill some pple, I’ve tried to nuke China when I got this tips so play as usuale.

    At a moment, a pop up should appear with a spontaneous infection of new guinea with contaminated blood shipped to them.

    And now, you can infect a closed country with a hight infectivity, transmission lvl 3 (animals or blood), environmental resistance, and may be drugs.

    have a fun !

  • big irms

    Necroa virus update finally here!! Here we go….

    • big irms

      Ok….done. Several new combo symptoms. Interesting changes. Beat casual and normal with no genetic modifications but had to use them for brutal. Couldn’t kill off humanity before the cure was discovered, had to always go the zombie route. So…racing for cure rate is almost pointless. You just have to make sure that you have enough DNA to get to the zombie mutation then get your undead army strong enough to infect the rest of the world before they decompose and die.

      If it is still needed, I will post symptoms and strategy in a couple of days…

  • Guest

    This needs to be updated for Necroa Virus

  • http://www.facebook.com/alyssa.sampson.100 Alyssa Sampson

    I’m not sure if anyone’s posted this, but here’s a strategy that worked for me to get the Plague in Space achievement. I chose Immune Plague, Normal difficulty. Genes were Catalytic Switch, Native Biome, Translesion, Darwinist, and Extremeophile. I started in the USA. My first points went into Drug Resistance 1, then Air 1, Water 1, Cold Resist 1, Heat Resist 1, Air 2, Water 2, Extreme Bioaerosol, Drug Resist 2, Cold Resist 2, Heat Resist 2, Environmental Hardening. Then go through Insomnia, Paranoia, Seizures, Insanity (It’s easiest if you grab them all at once) then devolve all but insanity. Wait. Let symptoms evolve, your plague will be noticed, but since it’s immune it doesn’t matter. After a while, you’ll get the notice for a space mission. Devolve all symptoms except insanity–it is very important to keep insanity. It might take a while. I ended up re-evolving insomnia and paranoia while waiting. Eventually, you will be told that they are launching the (apparently symptomless) astronauts. If you chose the catalytic switch, the blue bubbles you popped will have given you a lot of DNA. As tempting as it is, don’t go full throttle just yet. Evolve level 1 and 2 symptoms (maybe some 3), slowly choosing lethal symptoms. Keep the lethality low until you get the notice that the space launch failed, and then win the game. I hope this helps.

  • http://www.facebook.com/donovan.haupricht Donovan Haupricht

    Necroa Virus Symptom Combos discovered so far:

    Tank: Anabolic Boost + Bone Dysplasia
    Spitter: Naja Mortis + Enhanced Sensory Integration
    Sprinter: Enhanced Movement Control(?) + Engorged Quadriceps

    I will add more soon. All of these symptoms (except Bone Dysplasia) increase Necroa Virus severity.

    • big irms

      More Necroa Combos:

      Walking Contradiction Combo = photophobia + cathemeral
      shift; decreasing severity

      Blood in the Air Combo = delirium + hyperosmia ;
      increases severity

      • http://www.facebook.com/donovan.haupricht Donovan Haupricht

        Thanks.

        And here’s the last batch:

        Boomer: Autothysis + Liquefactive Necrosis (decreases zombie decay speed) = ???

        Bath Time: Polyphagia + Autophagia + Cannibalism = Severity

        Cranial Dispersion: Cranial Elephantitis (combat advantage; no severity) + Air 3 = Transmission(?)

        Vampire Bat: Vampiric Hunger (increases chance of zombie victims becoming zombies) + Bat 2 = Severity; also alerts zombies of nearby humans

        Plus Necroa Virus genes (only usable with Necroa Virus):

        Autolytic Reduction: Slightly reduces zombie decay speed

        Cytopathic Boost: Increases chance of infected corpses reanimating as zombies

        Spliced Activation: Active abilities cost less DNA to use

        ThermoNecro: Reduces zombie decay speed in hot countries

        Dopamine Inhibitor: Zombie victims are more likely to become zombies

        Necora Virus:

        Unclassified pathogen with extreme regeneration abilities, but the rest of it’s genetic code is a mystery. To win, you have to kill off the last human survivors OR turn them into zombies.

  • Robert Tiongson

    can you update for the necroa virus? interested in getting all achievements…

  • Hedrax

    Here is a combo, Boomer: Liquefied Organs + Authothysis; Increases severity.

    • Hedrax

      Vampire bat: Bat 2 + Vampiric Hunger

  • http://www.facebook.com/jeff.reid.5623 Jeff Reid

    I’ve noticed a lack of Insane Bolt guides. For anyone wondering about Insane Bolt I completed it in 262 days on casual. In Insane Bolt, Necrosis is your best friend. First, you’ll want to forget the transmissions exist unless you need ships or airplanes to be infected again (air1, water1). You’ll be doing most of your infecting using symptoms. Coughing, sneezing, pneumonia, rash, sweating, skin lesions, nausea, vomiting, the world should be relatively infected by then. Once you have most of the world infected, go for necrosis. as your DNA increases, get more symptoms. Try to get the infective ones first and the lethal ones last. You should be able to complete insane bolt rather easily if you follow these simple steps. Any questions or comments welcomed. Hope you found this useful.

  • EzioAuditore59

    Transmission

    Insect

    Insects susceptible to infection. Carriers increase infectivity, especially in hot climates and chance of mutation

    Zoonotic Shift

    Genetic shift in virus increases infectivity, mutation chance and makes cross species infection possible. Increases future research speed

    Bird 1

    Host range broadens to include birds. Increases infectivity, land transmission and mutation chance

    Bat 1

    Host range broadens to include bats which are hard to detect. Increases infectivity and mutation chance

    Rodent 1

    Host range broadens to include rats. Increases infectivity, especially in urban regions and mutation chance

    Bird 2

    Partial genetic activation triggers random bird attacks on humans. Significantly increases infectivity and land transmission

    Bat 2

    Partial genetic activation causes bats to mob and attack humans at night. Significantly increases infectivity and attacks can be lethal

    Rodent 2

    Partial genetic activation causes rat packs to attack humans. Significantly increases infectivity, especially in urban regions

    Saliva 1

    Virus replicates faster in salivary glands – increasing chance of infection through contact with saliva

    Saliva 2

    Virus replicates directly in nasal cavity – significantly increasing chance of infection through contact with mucus

    Gastrointestinal Expansion

    Virus can replicate in stomach and intestine, increasing infectiousness through faeces and vomit

    Urogenital Expansion

    Virus can replicate in kidneys and urinary tract, increasing infectiousness through urine and other bodily fluids

    Water 1

    Virus can survive outside the body in fresh, warm water. Increase infectivity, especially in humid environments and ship transmission

    Water 2

    Virus able to survive in chemically treated water. Increase infectivity, especially in humid environments and ship transmission

    Blood 1

    Virus enters the circulatory system, blood is now a transmission vector. Poor countries particularly vulnerable

    Blood 2

    Virus can replicate directly in the blood stream, significantly increasing infectivity. Poor countries particularly vulnerable

    Air 1

    Virus bypasses alveolar macrophages in lungs to enter bloodstream. Increase infectivity, especially in arid environments and plane transmission

    Air 2

    Virus can travel on dust particles. Increases infectivity, especially in arid environments and plane transmission

    Air 3

    Virus replicates rapidly in aerosoled brain matter. Significantly increases risk of infection if interacting with zombie brains

  • EzioAuditore59

    Symptom

    Autolytic Delay

    Virus slows release of digestive enzymes from cells’ lysosomes – slowing decomposition of corpse

    Putrefactive Resistance

    Virus prevents anaerobic microorganisms from digesting proteins – slowing decomposition of corpse

    Liquefactive Resistance

    Virus denatures hydrolytic enzymes, slowing liquefactive necrosis and decomposition of the corpse

    Segmented Genome

    Virus splits its genome into smaller molecules – increasing the likelihood of a viable mutation during transmission

    Insomnia

    Inability to sleep causes irritation and tiredness. Slows future research speed

    Photophobia

    Sensitivity and pain when eyes exposed to sunlight. Slows future research speed but slightly reduces infection rates

    Fever

    Increase in temperature causes general feeling of sickness and reduces concentration. Slows future research speed

    Coma

    Pressure buildup in the brain stem can cause loss of consciousness. Significantly slows future research speed but reduces infection rates

    Hyper Salivation

    Inflammation of the submandibular gland increases saliva production and infection rates

    Gastroenteritis

    Inflammation of the GI tract causes frequent vomiting. Significantly increases infection rates

    Polyphagia

    Compulsive hunger forces continuous eating. Lack of hygiene increases risk of infection

    Autophagia

    Compulsion to bite or partially devour own body – typically fingers or skin. Increases infection rates

    Cannibalism

    Extreme compulsion to bite and eat other humans – significantly increasing infectivity as well as lethality

    Psychosis

    Psychotic episodes lead to occasional bursts of extreme violence which can be lethal. Increases infectivity and slows future research speed

    Delirium

    Reduction in cognitive function causes irrationality and paranoia. Can be fatal and significantly slows future research speed

    Acute Encephalitis

    Multiple inflammatory lesions in the brain cause severe neurological damage resulting in death

    Cytopathic Reanimation

    Formation of complex neural structures enables re-animation of damaged cells and restoration of low level vitals. Turns dead into zombies

    Anaerobic Resuscitation

    Infected braincells switch to anaerobic respiration. Lactic acid buildup is lethal and destroys higher brain processes and personality

    Lumbrical Hypertrophy

    Significantly strengthens zombie grip making it nearly impossible for prey to break free. Severity significantly increased

    Peptide Surge

    Growth hormone production triggers extreme metabolism of fat to build muscle. Enhanced strength increases severity

    Anabolic Boost

    Surges of testosterone significantly increase muscle mass and weight of some zombies. Severity significantly increased

    Masticatory Tension

    Masticatory muscles become engorged, allowing zombie to bite through thick clothing. Severity increased

    Acidic Reflux

    Extreme laryngopharyngeal reflux causes acidic saliva. Increases severity and gives zombies a combat advantage

    Naja Mortis

    Muscle growth around submandibular duct lets some zombies projectile spit at prey. Increases severity and zombie combat advantage

    Autothysis

    Explosive mix of hydrogen sulphide and methane collects inside zombie. Significantly increases severity and zombie combat advantage

    Cranial Elephantitis

    Adenoma triggers mutated growth hormones which encourage bone growth in the skull. Gives zombie combat advantage

    Dermal Calcification

    Mutations in the endocrine system cause parts of skin to harden and calcify. Gives zombies a combat advantage

    Bone Dysplasia

    Increased bone density provides enhanced protection against trauma. Gives zombies a significant combat advantage

    Adrenal Surge

    Mutation of the adrenal cortex causes adrenaline over-production, increasing alertness and aggression of zombies

    Enhanced Motor Control

    Nutrient flow to the parietal lobe increased, improving movement and co-ordination. Increases severity, particularly in urban environments

    Enhanced Sensory Integration

    Nutrient flow to the occipital and temporal lobes increased. Enhanced sight and hearing increases severity

    Hyperosmia

    Thinning of the nasal epithelium significantly heightens zombie sense of smell. Increases severity

    Temporal Lobe Manipulation

    Zombies attracted to movement and will abandon victims once dead. Prey more likely to remain intact and become a zombie

    Vampiric Hunger

    Zombie prefers to suck the blood from its prey rather than eat the flesh. Prey more likely to remain intact and become a zombie

    Cathemeral Shift

    Stimulation of primary visual cortex improves vision in bright sunlight. Significantly increases severity

  • scwatergirl

    So I’m sure everyone has noticed that the strategies for necroa need to be a little different than just increasing transmissions and spreading the disease in stealth mode before making it lethal… I’ve found that you can just pick your country of origin and just wait without using any DNA points (you have to have patience) and the disease spreads itself pretty nicely without being noticed at all. I usually start in China because of the population density.

    • scwatergirl

      And then I go crazy on evolving symptoms and zombie traits :)

  • Petr

    Hi can somebody help me? I have almost all types of plaque won on brutal bud i cant win fungus. Some tips? Thanx

    • http://www.facebook.com/thesteeljackal William O’Sullivan

      I’m just after beating it, no genes. Here’s what I did:

      1)Start in China. Don’t upgrade any symptoms until the end. This is critical.

      2)Upgrade Air 1,2 & Water 1,2 and unlock Bioaerosol.

      3)Upgrade Cold Resistance 1 & Heat Resistance 1.

      4) Upgrade Drug Resistance 1,2.

      5) Bank points until everyone is infected.

      6) Unlock Cysts, Hypersensitivity, Paralysis, Coma, Total Organ Failure.

      7) You will spend all of your points on symptoms, but you’ll earn them from deaths. Use new points for reshuffles.

      8) Win. You’re welcome :D

      • http://www.facebook.com/thesteeljackal William O’Sullivan

        Also, when you get about 30 points from the kills get genetic hardening 1

      • Pete Scott

        we are welcome????For whaT?
        You telling us how to waste dna??

  • Andrew

    I’ve notice that, on the necroa virus, some people have figured ou how to use the special abilities for free, like the horde, its free. is this a hack, do you have to buy it, or can you get it normally on the game?

  • Peter Terras

    Has anyone achieved the “Not another zombie game” with the Necroa virus yet?

  • Jumjum

    Here’s a quick guide on how I scored 754880 points using parasite on brutal:

    The two key mutations are Genetic Mimic and Sympto-Stasis. I started in China.

    Only devolve the lethal symptoms and use Symbiosis 1-3 to keep severity under 6 until ca 85% infection in China. Then severity has to be 0 to stay undetected.

    Get Drug Resistance 1 and, only if needed to infect islands, Water 1. Nothing else.

    Keep devolving only the lethal symptoms until severity can’t be kept at zero anymore. (Took me 9 years…) Then evolve all symptoms and Genetic Hardening 1+2 right away. Use incoming dna from deaths for the rest of the cure abilities. Profit!

    • Jumjum

      When evolving all symptoms you naturally devolve Symbiosis 1-3 too.

  • Cherry

    Question: this thought has always plagued my mind, I’ve always wondered what the “RMS” stand for, I have tried googling it but there’s a lot of acronyms for it. Does anyone here know?

  • RAZZER

    ha ha ha I have finished the game XD

  • mithsadei

    Does anyone know what each of the sound clips mean? I read on another site that they’re supposed to give you hints to what would be an effective evolution at that time, but I haven’t been able to find any sort of guide to what each sound means. Some are easy, like the coughing, but others, such as the crying girl, I just don’t get.

    Also, a price list of each ability would be nice. I know the prices go up with each purchase, but a chart could be done (e.x. coughing: 4, 5, 7, 10) scaling up for each other ability purchased.

    • Lady_Hiroko

      I think it’s just to make it more “fun” or “real” rather than “hints”. The sounds I get usually correlates with the symptoms I have active. If I have coughing enabled, I get the “coughing” sound. If I have Stomach bug (or whatever), I get the girl crying. If it’s lethal, the ambulance. Airborne transmission, a pilot speaking on the PA. You get the idea.

  • hurrimadurr

    Okay, this game is absolute bullshit.
    I get all the cure defense I can (Insomnia, Paranoia, Insanity, Coma, Paralysis) and the best killer (TOF) and the cure will STILL be ready in less than a year! And TOF won’t kill fast enough to recoup my investments before the cure is over 50-70%! I can never, ever, EVER get a score lower than 30%! It’s fucking impossible!

    • Peter Terras

      Spread your infection with transmissions and non lethal sysmptoms first until you get the disease going, then ramp up the symptoms adding ones with low lethality and higher severity before going lethal with TOF, IH, etc.

      If you go lethal too quickly you’ll kill the infected people before they can transmit the disease to others.

    • Lady_Hiroko

      The strategy I always used with the exception of Nano and Bio on Brutal (haven’t figured those out yet), is to boost up transmission first, then your resistances (reshuffle and the like) along with the opposite temp resistance from the country you started in (I nearly always start in Egypt which is hot so I boost cold because I already have that “hot” resistance), rake in the points from the infected (depending on which one you’re doing will determine how fast), devolve unnecessary symptoms (exception of Virus because you’ll LOSE points rather than gain), then start out with the killer: coughing, fibrosis, etc until you get TOF, then go after Insomnia skipping paralysis (?) going straight to insanity. You probably won’t get 5 Bio Hazards (I normally get 4). But you still win. Try unlocking the cheats before getting the achievements/5 Bios. That way, you’ll get a better idea of which strategy to choose through trial-and-error.

      I haven’t tried the newer ones: Nuerax Worm and Necroa.

      I basically just explained–in more simplicity–what Peter Terras said.

  • Akshay

    I hate when this game glitches… ok it happened like 1 game out of about 15 I’ve played but still it’s annoying! For some reason, my plague stopped spreading in Greenland and Iceland. Greenland had 14 infected, Iceland had 15, and it stayed that way until I gave up and quit. My infectivity was super high (85) so it was obviously a glitch….

  • steve rackwood

    Who on earth thinks this is easy? Have tried about 5 times on normal and can’t win. Once the research starts, you have no chance. You never get any more DNA points to slow down the cure, so you are left watching your plan fail and are powerless to stop it. Very frustrating.

    There are no help websites that will at least give you a plan other than explaining what each thing does. Sure, I know how to increase the time for a cure, but I had to use all of my DNA points to get it to infect everyone first.

    Unless there is a step by step plan out there, I am calling BS on all of you who say “this game is so easy”. I can win the first level 100% of the time on casual, but normal has an impossible endgame. There are always a few million survivors no matter what.

    • big irms

      Steve – spend some time combing through and reading this discussion. there are some fool proof ways to beat this game all the way to brutal.

  • big irms

    Scenerios! Just in time for the long weekend! It’s been too long since I’ve had a reason to play.

  • Arcan

    Has anyone mentioned using the Patho-Stasis gene while playing as fungus? Just put your first point into spore burst, and use the point earned from that for the next spore burst etc. until you’ve purchased all of the fungus abilities. This’ll get you an infection in about 20 countries in less than 2 weeks.

  • Ronan Fitzgerald

    wow….awesome.

  • Ronan Fitzgerald

    Necroa and mind-worm have very different play styles from the others…Necroa has a much more outright feel, as you can skip being stealthy (at the start) and then go crazy zombiefying everyone. mind-worm…you don’t need to kill ANYONE. just infect them all, then get everyone to worship you. also…the cheat plagues are SOOOOOOO much fun. You can infect the world in >2 months, then kill everyone in about that same time span and keep your cure at 33% or somethin

  • Ronan Fitzgerald

    2 more points…anyone else want the cheats to be pairable with any other virus type? Infinite credit zambiez…and second, people are worried about FPS’s but not games were you destroy all of humanity

  • EzioAuditore59

    Neurax Worm Transmission

    Air 3

    Waxy membranes allow survival in air conditioning vents and other arid locations. Increased infectivity, especially in rich and hot countries

    Air 2

    Carapace becomes lighter, increasing infectivity, especially in arid conditions and planes

    Air 1

    Worm can dehydrate to become lighter, allowing them to float on wind, increasing infectivity, especially in arid conditions and planes

    Undulatory Locomotion

    Ability to propagate flexural waves along the length of worm allows an increase in speed and range outside host, increasing infectiousness

    Concertina Locomotion

    Ability to grip with portions of the body while pulling/pushing other sections allows faster movement outside host, increasing infectivity

    Water 1

    Worm skin becomes highly vascularised allowing absorption of oxygen, survival and transmission in water.

    Water 2

    Worms develop a more flexible cell membrane, which allows them to survive at a range of depths

    Water 3

    Worm eggs gain ability to thrive in unsanitised water, greatly increasing infectivity especially in poor countries

    Eggs 2

    Eggs hatch when they experience an increase in warmth, likely due to nearby human activity, greatly increasing infection

    Eggs 1

    The Neurax worm produces eggs that are ejected from the host brain in the thousands, increasing infectiousness

    Bird 1

    Worms become a food source for birds, but many survive in the digestive tract, allowing increased transmission

    Bird 2

    Worms develop the ability to breed in the bird’s digestive tract, allowing greater distribution and transmission

    Insect 1

    Worm eggs attach themselves to insects, causing increased infectiousness, especially in hot climates

    Insect 2

    Attaching to a greater range of insects allows a large increase in infection, especially in hot climates

    Rodent 1

    Worm eggs attach themselves to the fur of rats, which increases their infectiousness, especially in urban environments

    Rodent 2

    Worm eggs secrete neurochemical that drives rats to attack humans, increasing infectivity, especially in urban environments

    Genetic Swap

    Worms able to exchange genetic material inside host body, increasing chance of mutation

    Mutative Regeneration 1

    Fragmented RNA strands causes frequent replication errors when regenerating and an increased chance of mutation

    Mutative Regeneration 2

    Degradation of the nuclear membrane makes the worm highly prone to mutation

    Corpse Feeder 1

    Worms drawn to corpses, increasing infectivity when corpses present

    Corpse Feeder 2

    Worms undergo feeding frenzy in corpses, significantly increasing infectivity when corpses present

    • http://www.deltaattack.com/ Markham Asylum

      These have been added to the guide. Thanks Ezio!

  • EzioAuditore59

    Mr. Markham Asylum, those are Neurax Worm transmissions, not abilities :)

  • EzioAuditore59

    For Necroa Virus Exclusive symptoms, Autolytic Delay, Liquefactive Resistance and Putrefactive Resistance are Active Abilities (reduces zombies’ decomposition rate). And Segmented Genome is a Transmission trait.

  • Motoko Coeman

    Anothet thing goverment does for trying to stop the cure. Is to bomb the infected cities. Or to execute the infected people. At least in brutal mode.